Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease
Non-steroidal Anti-inflammatory drugs (NSAID)-exacerbated respiratory disease (N-ERD) is characterized by nasal polyposis, chronic rhinosinusitis, adult-onset asthma and hypersensitive reactions to cyclooxygenase-1 (COX-1) inhibitors. Among the available treatments for this disease, a combination of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.695815/full |
| _version_ | 1818872193088487424 |
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| author | Esha Sehanobish Esha Sehanobish Mohammad Asad Mohammad Asad Mali Barbi Steven A. Porcelli Steven A. Porcelli Elina Jerschow Elina Jerschow |
| author_facet | Esha Sehanobish Esha Sehanobish Mohammad Asad Mohammad Asad Mali Barbi Steven A. Porcelli Steven A. Porcelli Elina Jerschow Elina Jerschow |
| author_sort | Esha Sehanobish |
| collection | DOAJ |
| description | Non-steroidal Anti-inflammatory drugs (NSAID)-exacerbated respiratory disease (N-ERD) is characterized by nasal polyposis, chronic rhinosinusitis, adult-onset asthma and hypersensitive reactions to cyclooxygenase-1 (COX-1) inhibitors. Among the available treatments for this disease, a combination of endoscopic sinus surgery followed by aspirin desensitization and aspirin maintenance therapy has been an effective approach. Studies have shown that long-term aspirin maintenance therapy can reduce the rate of nasal polyp recurrence in patients with N-ERD. However, the exact mechanism by which aspirin can both trigger and suppress airway disease in N-ERD remains poorly understood. In this review, we summarize current knowledge of aspirin effects in N-ERD, cardiovascular disease, and cancer, and consider potential mechanistic pathways accounting for the effects of aspirin in N-ERD. |
| first_indexed | 2024-12-19T12:34:55Z |
| format | Article |
| id | doaj.art-1d3bec951efd4bfcb091a3c43b09909c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T12:34:55Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1d3bec951efd4bfcb091a3c43b09909c2022-12-21T20:21:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-06-011210.3389/fimmu.2021.695815695815Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory DiseaseEsha Sehanobish0Esha Sehanobish1Mohammad Asad2Mohammad Asad3Mali Barbi4Steven A. Porcelli5Steven A. Porcelli6Elina Jerschow7Elina Jerschow8Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United StatesNon-steroidal Anti-inflammatory drugs (NSAID)-exacerbated respiratory disease (N-ERD) is characterized by nasal polyposis, chronic rhinosinusitis, adult-onset asthma and hypersensitive reactions to cyclooxygenase-1 (COX-1) inhibitors. Among the available treatments for this disease, a combination of endoscopic sinus surgery followed by aspirin desensitization and aspirin maintenance therapy has been an effective approach. Studies have shown that long-term aspirin maintenance therapy can reduce the rate of nasal polyp recurrence in patients with N-ERD. However, the exact mechanism by which aspirin can both trigger and suppress airway disease in N-ERD remains poorly understood. In this review, we summarize current knowledge of aspirin effects in N-ERD, cardiovascular disease, and cancer, and consider potential mechanistic pathways accounting for the effects of aspirin in N-ERD.https://www.frontiersin.org/articles/10.3389/fimmu.2021.695815/fullN-ERDaspirinCOX-1 inhibitorNSAIDsnasal polypsprostaglandins |
| spellingShingle | Esha Sehanobish Esha Sehanobish Mohammad Asad Mohammad Asad Mali Barbi Steven A. Porcelli Steven A. Porcelli Elina Jerschow Elina Jerschow Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease Frontiers in Immunology N-ERD aspirin COX-1 inhibitor NSAIDs nasal polyps prostaglandins |
| title | Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease |
| title_full | Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease |
| title_fullStr | Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease |
| title_full_unstemmed | Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease |
| title_short | Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease |
| title_sort | aspirin actions in treatment of nsaid exacerbated respiratory disease |
| topic | N-ERD aspirin COX-1 inhibitor NSAIDs nasal polyps prostaglandins |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.695815/full |
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