Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to Histology
Calcifications are common in the tunica intima and tunica media of leg arteries. There is growing interest in medial arterial calcifications, as they may be modifiable with treatment. We aimed to investigate radiography and computed tomography (CT) for the detection and characterization of both type...
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MDPI AG
2022-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/5/711 |
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| author | Annelotte Vos Aryan Vink Remko Kockelkoren Richard A. P. Takx Csilla Celeng Willem P. T. M. Mali Ivana Isgum Ronald L. A. W. Bleys Pim A. de Jong |
| author_facet | Annelotte Vos Aryan Vink Remko Kockelkoren Richard A. P. Takx Csilla Celeng Willem P. T. M. Mali Ivana Isgum Ronald L. A. W. Bleys Pim A. de Jong |
| author_sort | Annelotte Vos |
| collection | DOAJ |
| description | Calcifications are common in the tunica intima and tunica media of leg arteries. There is growing interest in medial arterial calcifications, as they may be modifiable with treatment. We aimed to investigate radiography and computed tomography (CT) for the detection and characterization of both types of arterial calcification in leg arteries in relation to histology. In a postmortem study we therefore investigated 24 popliteal and 24 tibial arteries. The reference standard was presence of arterial calcification and the dominance of intimal or medial calcification on histology. Radiographs and CT scans were scored for presence of calcification and for dominant intimal or medial pattern based on prespecified criteria (annularity, thickness, continuity). Both radiography and CT detected 87% of histologically proven calcifications but missed mild calcifications in 13%. When only the arteries with detected calcifications were included, a moderate agreement was observed on intimal/medial location of calcifications between histology and radiography (correct in 19/24 arteries (79%); Kappa 0.58) or CT (correct in 33/46 arterial segments (72%); Kappa 0.48). With both modalities there was a slight tendency to classify intimal calcifications as being located in the media and to miss media calcification. Our study demonstrates the potential and limitations of both radiography and CT to detect and classify arterial calcifications in leg arteries. |
| first_indexed | 2024-03-10T03:36:24Z |
| format | Article |
| id | doaj.art-1d3cb45bbe334526b22381d4986a1c13 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T03:36:24Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-1d3cb45bbe334526b22381d4986a1c132023-11-23T11:43:32ZengMDPI AGJournal of Personalized Medicine2075-44262022-04-0112571110.3390/jpm12050711Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to HistologyAnnelotte Vos0Aryan Vink1Remko Kockelkoren2Richard A. P. Takx3Csilla Celeng4Willem P. T. M. Mali5Ivana Isgum6Ronald L. A. W. Bleys7Pim A. de Jong8Department of Pathology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Pathology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Anatomy, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The NetherlandsCalcifications are common in the tunica intima and tunica media of leg arteries. There is growing interest in medial arterial calcifications, as they may be modifiable with treatment. We aimed to investigate radiography and computed tomography (CT) for the detection and characterization of both types of arterial calcification in leg arteries in relation to histology. In a postmortem study we therefore investigated 24 popliteal and 24 tibial arteries. The reference standard was presence of arterial calcification and the dominance of intimal or medial calcification on histology. Radiographs and CT scans were scored for presence of calcification and for dominant intimal or medial pattern based on prespecified criteria (annularity, thickness, continuity). Both radiography and CT detected 87% of histologically proven calcifications but missed mild calcifications in 13%. When only the arteries with detected calcifications were included, a moderate agreement was observed on intimal/medial location of calcifications between histology and radiography (correct in 19/24 arteries (79%); Kappa 0.58) or CT (correct in 33/46 arterial segments (72%); Kappa 0.48). With both modalities there was a slight tendency to classify intimal calcifications as being located in the media and to miss media calcification. Our study demonstrates the potential and limitations of both radiography and CT to detect and classify arterial calcifications in leg arteries.https://www.mdpi.com/2075-4426/12/5/711vascular calcificationcomputed tomographyradiographyhistologymedial arterial calcificationatherosclerosis |
| spellingShingle | Annelotte Vos Aryan Vink Remko Kockelkoren Richard A. P. Takx Csilla Celeng Willem P. T. M. Mali Ivana Isgum Ronald L. A. W. Bleys Pim A. de Jong Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to Histology Journal of Personalized Medicine vascular calcification computed tomography radiography histology medial arterial calcification atherosclerosis |
| title | Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to Histology |
| title_full | Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to Histology |
| title_fullStr | Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to Histology |
| title_full_unstemmed | Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to Histology |
| title_short | Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to Histology |
| title_sort | radiography and computed tomography detection of intimal and medial calcifications in leg arteries in comparison to histology |
| topic | vascular calcification computed tomography radiography histology medial arterial calcification atherosclerosis |
| url | https://www.mdpi.com/2075-4426/12/5/711 |
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