Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
PDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13331-x |
| _version_ | 1818342679539351552 |
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| author | Fan Sun Liwen Li Pengrong Yan Jingjiao Zhou Steven D. Shapiro Gutian Xiao Zhaoxia Qu |
| author_facet | Fan Sun Liwen Li Pengrong Yan Jingjiao Zhou Steven D. Shapiro Gutian Xiao Zhaoxia Qu |
| author_sort | Fan Sun |
| collection | DOAJ |
| description | PDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers. |
| first_indexed | 2024-12-13T16:18:31Z |
| format | Article |
| id | doaj.art-1d400ac3bbf44a7799867ab4feea7bfd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:18:31Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1d400ac3bbf44a7799867ab4feea7bfd2022-12-21T23:38:47ZengNature PortfolioNature Communications2041-17232019-11-0110111310.1038/s41467-019-13331-xCausative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistanceFan Sun0Liwen Li1Pengrong Yan2Jingjiao Zhou3Steven D. Shapiro4Gutian Xiao5Zhaoxia Qu6UPMC Hillman Cancer CenterUPMC Hillman Cancer CenterUPMC Hillman Cancer CenterUPMC Hillman Cancer CenterDepartment of Medicine, University of Pittsburgh Medical Center, University of PittsburghUPMC Hillman Cancer CenterUPMC Hillman Cancer CenterPDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers.https://doi.org/10.1038/s41467-019-13331-x |
| spellingShingle | Fan Sun Liwen Li Pengrong Yan Jingjiao Zhou Steven D. Shapiro Gutian Xiao Zhaoxia Qu Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance Nature Communications |
| title | Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance |
| title_full | Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance |
| title_fullStr | Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance |
| title_full_unstemmed | Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance |
| title_short | Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance |
| title_sort | causative role of pdlim2 epigenetic repression in lung cancer and therapeutic resistance |
| url | https://doi.org/10.1038/s41467-019-13331-x |
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