Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing
Infected wound healing remains a significant issue in clinical medicine and has attracted wide attention in the field of biomedical engineering. Although a range of bioactive materials have been developed, few provide sufficient antibacterial and pro-angiogenic effects for effective wound healing. H...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523000850 |
| _version_ | 1811158423053533184 |
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| author | Yanan Zhao Yiming Liu Chuan Tian Zaoqu Liu Kunpeng Wu Chengzhi Zhang Xinwei Han |
| author_facet | Yanan Zhao Yiming Liu Chuan Tian Zaoqu Liu Kunpeng Wu Chengzhi Zhang Xinwei Han |
| author_sort | Yanan Zhao |
| collection | DOAJ |
| description | Infected wound healing remains a significant issue in clinical medicine and has attracted wide attention in the field of biomedical engineering. Although a range of bioactive materials have been developed, few provide sufficient antibacterial and pro-angiogenic effects for effective wound healing. Herein, we constructed a series of nanofibers (termed PL-n, n = 0, 1, and 2) based on polycaprolactone (PCL), nanosilvers (AgNPs) and black phosphorus (BP) using electrospinning technology. The water contact angle of PL-n decreased significantly from 144.00 ± 1.00° for PL-0 to 0° for PL-2. The photothermal temperature increased significantly from 27.27 ± 0.25 °C for PL-0 to 40.7 ± 0.15 °C for PL-2. After exposure to near-infrared ray (NIR), the release rate of PL-2 increased from 78.00 ± 2.95 % to 89.46 ± 2.05 %. Biological experiments demonstrated that NIR-assisted PL-2 has excellent antibacterial and biofilm ablation activity with good biocompatibility. Furthermore, in vivo studies indicated that the NIR-assisted PL-2 accelerated wound healing by stimulating granulation tissue formation, collagen deposition, and angiogenesis and decreasing expression levels of CD68. The study suggests that this bi-functional nanofiber is indeed a versatile wound dressing, and is expected to be applied in clinical settings. |
| first_indexed | 2024-04-10T05:24:25Z |
| format | Article |
| id | doaj.art-1d41030ce3ea47f0b4988e3196854c52 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T05:24:25Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-1d41030ce3ea47f0b4988e3196854c522023-03-08T04:13:48ZengElsevierMaterials & Design0264-12752023-02-01226111670Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healingYanan Zhao0Yiming Liu1Chuan Tian2Zaoqu Liu3Kunpeng Wu4Chengzhi Zhang5Xinwei Han6Department of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Corresponding authors at: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450000, P. R. China.Department of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Department of Interventional Medical Center, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Shandong, 266000, Qingdao, ChinaDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Interventional Radiology, Key Laboratory of Interventional Radiology of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Corresponding authors at: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450000, P. R. China.Infected wound healing remains a significant issue in clinical medicine and has attracted wide attention in the field of biomedical engineering. Although a range of bioactive materials have been developed, few provide sufficient antibacterial and pro-angiogenic effects for effective wound healing. Herein, we constructed a series of nanofibers (termed PL-n, n = 0, 1, and 2) based on polycaprolactone (PCL), nanosilvers (AgNPs) and black phosphorus (BP) using electrospinning technology. The water contact angle of PL-n decreased significantly from 144.00 ± 1.00° for PL-0 to 0° for PL-2. The photothermal temperature increased significantly from 27.27 ± 0.25 °C for PL-0 to 40.7 ± 0.15 °C for PL-2. After exposure to near-infrared ray (NIR), the release rate of PL-2 increased from 78.00 ± 2.95 % to 89.46 ± 2.05 %. Biological experiments demonstrated that NIR-assisted PL-2 has excellent antibacterial and biofilm ablation activity with good biocompatibility. Furthermore, in vivo studies indicated that the NIR-assisted PL-2 accelerated wound healing by stimulating granulation tissue formation, collagen deposition, and angiogenesis and decreasing expression levels of CD68. The study suggests that this bi-functional nanofiber is indeed a versatile wound dressing, and is expected to be applied in clinical settings.http://www.sciencedirect.com/science/article/pii/S0264127523000850Wound dressingAntibacterial activityHot spring effectAngiogenesisInfected wound healing |
| spellingShingle | Yanan Zhao Yiming Liu Chuan Tian Zaoqu Liu Kunpeng Wu Chengzhi Zhang Xinwei Han Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing Materials & Design Wound dressing Antibacterial activity Hot spring effect Angiogenesis Infected wound healing |
| title | Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing |
| title_full | Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing |
| title_fullStr | Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing |
| title_full_unstemmed | Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing |
| title_short | Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing |
| title_sort | construction of antibacterial photothermal pcl agnps bp nanofibers for infected wound healing |
| topic | Wound dressing Antibacterial activity Hot spring effect Angiogenesis Infected wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523000850 |
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