Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies
Abstract Mental disorders widely contribute to the modern global disease burden, creating a significant need for improvement of treatments. Scalp stimulation methods (such as scalp acupuncture and transcranial electrical stimulation) have shown promising results in relieving psychiatric symptoms. Ho...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-021-02993-1 |
| _version_ | 1818646460443394048 |
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| author | Jin Cao Thalia Celeste Chai-Zhang Yiting Huang Maya Nicole Eshel Jian Kong |
| author_facet | Jin Cao Thalia Celeste Chai-Zhang Yiting Huang Maya Nicole Eshel Jian Kong |
| author_sort | Jin Cao |
| collection | DOAJ |
| description | Abstract Mental disorders widely contribute to the modern global disease burden, creating a significant need for improvement of treatments. Scalp stimulation methods (such as scalp acupuncture and transcranial electrical stimulation) have shown promising results in relieving psychiatric symptoms. However, neuroimaging findings haven’t been well-integrated into scalp stimulation treatments. Identifying surface brain regions associated with mental disorders would expand target selection and the potential for these interventions as treatments for mental disorders. In this study, we performed large-scale meta-analyses separately on eight common mental disorders: attention deficit hyperactivity disorder, anxiety disorder, autism spectrum disorder, bipolar disorder, compulsive disorder, major depression, post-traumatic stress disorder and schizophrenia; utilizing modern neuroimaging literature to summarize disorder-associated surface brain regions, and proposed neuroimaging-based target protocols. We found that the medial frontal gyrus, the supplementary motor area, and the dorsal lateral prefrontal cortex are commonly involved in the pathophysiology of mental disorders. The target protocols we proposed may provide new brain targets for scalp stimulation in the treatment of mental disorders, and facilitate its clinical application. |
| first_indexed | 2024-12-17T00:46:59Z |
| format | Article |
| id | doaj.art-1d415f2beb66444fa4eea77da8485ce3 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-17T00:46:59Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-1d415f2beb66444fa4eea77da8485ce32022-12-21T22:09:52ZengBMCJournal of Translational Medicine1479-58762021-08-0119112810.1186/s12967-021-02993-1Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studiesJin Cao0Thalia Celeste Chai-Zhang1Yiting Huang2Maya Nicole Eshel3Jian Kong4Department of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolAbstract Mental disorders widely contribute to the modern global disease burden, creating a significant need for improvement of treatments. Scalp stimulation methods (such as scalp acupuncture and transcranial electrical stimulation) have shown promising results in relieving psychiatric symptoms. However, neuroimaging findings haven’t been well-integrated into scalp stimulation treatments. Identifying surface brain regions associated with mental disorders would expand target selection and the potential for these interventions as treatments for mental disorders. In this study, we performed large-scale meta-analyses separately on eight common mental disorders: attention deficit hyperactivity disorder, anxiety disorder, autism spectrum disorder, bipolar disorder, compulsive disorder, major depression, post-traumatic stress disorder and schizophrenia; utilizing modern neuroimaging literature to summarize disorder-associated surface brain regions, and proposed neuroimaging-based target protocols. We found that the medial frontal gyrus, the supplementary motor area, and the dorsal lateral prefrontal cortex are commonly involved in the pathophysiology of mental disorders. The target protocols we proposed may provide new brain targets for scalp stimulation in the treatment of mental disorders, and facilitate its clinical application.https://doi.org/10.1186/s12967-021-02993-1NeuroimagingMeta-analysisScalp stimulationScalp acupunctureTranscranial electrical stimulationMental disorder |
| spellingShingle | Jin Cao Thalia Celeste Chai-Zhang Yiting Huang Maya Nicole Eshel Jian Kong Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies Journal of Translational Medicine Neuroimaging Meta-analysis Scalp stimulation Scalp acupuncture Transcranial electrical stimulation Mental disorder |
| title | Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies |
| title_full | Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies |
| title_fullStr | Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies |
| title_full_unstemmed | Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies |
| title_short | Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies |
| title_sort | potential scalp stimulation targets for mental disorders evidence from neuroimaging studies |
| topic | Neuroimaging Meta-analysis Scalp stimulation Scalp acupuncture Transcranial electrical stimulation Mental disorder |
| url | https://doi.org/10.1186/s12967-021-02993-1 |
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