Calprotectin as a diagnostic marker for sepsis: A meta-analysis
IntroductionSepsis is a life-threatening condition, and biomarkers are needed to diagnose sepsis fast and accurately. We aimed to perform this meta-analysis to investigate the diagnostic value of calprotectin on sepsis in critically ill patients.MethodsThe investigators searched MEDLINE, Embase, Web...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1045636/full |
| _version_ | 1811303603270320128 |
|---|---|
| author | Rong-Yue Gao Hui-Miao Jia Yu-Zhen Han Ben-Shu Qian Pan You Xiao-Ke Zhang Wen-Xiong Li Li-Feng Huang |
| author_facet | Rong-Yue Gao Hui-Miao Jia Yu-Zhen Han Ben-Shu Qian Pan You Xiao-Ke Zhang Wen-Xiong Li Li-Feng Huang |
| author_sort | Rong-Yue Gao |
| collection | DOAJ |
| description | IntroductionSepsis is a life-threatening condition, and biomarkers are needed to diagnose sepsis fast and accurately. We aimed to perform this meta-analysis to investigate the diagnostic value of calprotectin on sepsis in critically ill patients.MethodsThe investigators searched MEDLINE, Embase, Web of Science and Cochrane Library. Studies were included if they assessed the diagnostic accuracy of serum calprotectin for sepsis in intensive care unit (ICU). We estimated its diagnostic value and explored the source of heterogeneity. The bivariate model and the hierarchical summary receiver operating characteristic (HSROC) curve were used in the meta-analysis.ResultsSix records assessing 821 patients were included in this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), and diagnostic odds ratio (DOR) were separately as 0.77, 0.85, 5.20, 0.27, respectively. The Fagan's nomogram showed post‐test probabilities of 91% and 35% for positive and negative outcomes, respectively. Subgroup analysis indicated that sepsis definition could be a possible source of heterogeneity, but there’s no sufficient data to investigate sepsis-3 definition. Sensitivity analysis suggested that two studies could affect the stability of pooled results.ConclusionOn the basis of our meta-analysis, calprotectin is a helpful marker for early diagnosis of sepsis on ICU admission. |
| first_indexed | 2024-04-13T07:49:53Z |
| format | Article |
| id | doaj.art-1d43c56eef3746388b870edc955d6ea1 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T07:49:53Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-1d43c56eef3746388b870edc955d6ea12022-12-22T02:55:33ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-11-011210.3389/fcimb.2022.10456361045636Calprotectin as a diagnostic marker for sepsis: A meta-analysisRong-Yue GaoHui-Miao JiaYu-Zhen HanBen-Shu QianPan YouXiao-Ke ZhangWen-Xiong LiLi-Feng HuangIntroductionSepsis is a life-threatening condition, and biomarkers are needed to diagnose sepsis fast and accurately. We aimed to perform this meta-analysis to investigate the diagnostic value of calprotectin on sepsis in critically ill patients.MethodsThe investigators searched MEDLINE, Embase, Web of Science and Cochrane Library. Studies were included if they assessed the diagnostic accuracy of serum calprotectin for sepsis in intensive care unit (ICU). We estimated its diagnostic value and explored the source of heterogeneity. The bivariate model and the hierarchical summary receiver operating characteristic (HSROC) curve were used in the meta-analysis.ResultsSix records assessing 821 patients were included in this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), and diagnostic odds ratio (DOR) were separately as 0.77, 0.85, 5.20, 0.27, respectively. The Fagan's nomogram showed post‐test probabilities of 91% and 35% for positive and negative outcomes, respectively. Subgroup analysis indicated that sepsis definition could be a possible source of heterogeneity, but there’s no sufficient data to investigate sepsis-3 definition. Sensitivity analysis suggested that two studies could affect the stability of pooled results.ConclusionOn the basis of our meta-analysis, calprotectin is a helpful marker for early diagnosis of sepsis on ICU admission.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1045636/fullcalprotectinsepsisdiagnosismeta-analysisbiomarker |
| spellingShingle | Rong-Yue Gao Hui-Miao Jia Yu-Zhen Han Ben-Shu Qian Pan You Xiao-Ke Zhang Wen-Xiong Li Li-Feng Huang Calprotectin as a diagnostic marker for sepsis: A meta-analysis Frontiers in Cellular and Infection Microbiology calprotectin sepsis diagnosis meta-analysis biomarker |
| title | Calprotectin as a diagnostic marker for sepsis: A meta-analysis |
| title_full | Calprotectin as a diagnostic marker for sepsis: A meta-analysis |
| title_fullStr | Calprotectin as a diagnostic marker for sepsis: A meta-analysis |
| title_full_unstemmed | Calprotectin as a diagnostic marker for sepsis: A meta-analysis |
| title_short | Calprotectin as a diagnostic marker for sepsis: A meta-analysis |
| title_sort | calprotectin as a diagnostic marker for sepsis a meta analysis |
| topic | calprotectin sepsis diagnosis meta-analysis biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1045636/full |
| work_keys_str_mv | AT rongyuegao calprotectinasadiagnosticmarkerforsepsisametaanalysis AT huimiaojia calprotectinasadiagnosticmarkerforsepsisametaanalysis AT yuzhenhan calprotectinasadiagnosticmarkerforsepsisametaanalysis AT benshuqian calprotectinasadiagnosticmarkerforsepsisametaanalysis AT panyou calprotectinasadiagnosticmarkerforsepsisametaanalysis AT xiaokezhang calprotectinasadiagnosticmarkerforsepsisametaanalysis AT wenxiongli calprotectinasadiagnosticmarkerforsepsisametaanalysis AT lifenghuang calprotectinasadiagnosticmarkerforsepsisametaanalysis |