Construction Methods and Influencing Factors on Animal Model of Sepsis
Sepsis is a common acute and critical illness, and its pathogenic mechanism is complex, often involving multiple organs and systems in the body. Various factors such as inflammatory response, immune dysfunction, and coagulation dysfunction are connected into an interconnected and mutually influencin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Laboratory Animal and Comparative Medicine
2022-06-01
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| Series: | Shiyan dongwu yu bijiao yixue |
| Subjects: | |
| Online Access: | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.121 |
| _version_ | 1798016459679465472 |
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| author | LI Xiao YAN Haipeng XIAO Zhenghui |
| author_facet | LI Xiao YAN Haipeng XIAO Zhenghui |
| author_sort | LI Xiao |
| collection | DOAJ |
| description | Sepsis is a common acute and critical illness, and its pathogenic mechanism is complex, often involving multiple organs and systems in the body. Various factors such as inflammatory response, immune dysfunction, and coagulation dysfunction are connected into an interconnected and mutually influencing network system, aggravating the severity of the disease. At present, the case fatality rate of sepsis is about 25%, which is a serious threat to human health. Establishing a stable and reliable experimental animal model of sepsis is an important means to understand the mechanism of host defense regulation in the early stage of infection, the mechanism of host response disorder in the stage of disease progression and to study the therapeutic effect of new therapeutic drugs. At present, there are many methods to establish animal models of sepsis, and there are many influencing factors. Therefore, this paper reviewed the preparation methods and influencing factors of animal models of sepsis, in order to provide some references for researchers to select suitable animal models. |
| first_indexed | 2024-04-11T15:51:02Z |
| format | Article |
| id | doaj.art-1d44ff20134d468abd33d73af787f3ee |
| institution | Directory Open Access Journal |
| issn | 1674-5817 |
| language | zho |
| last_indexed | 2024-04-11T15:51:02Z |
| publishDate | 2022-06-01 |
| publisher | Editorial Office of Laboratory Animal and Comparative Medicine |
| record_format | Article |
| series | Shiyan dongwu yu bijiao yixue |
| spelling | doaj.art-1d44ff20134d468abd33d73af787f3ee2022-12-22T04:15:17ZzhoEditorial Office of Laboratory Animal and Comparative MedicineShiyan dongwu yu bijiao yixue1674-58172022-06-0142320721210.12300/j.issn.1674-5817.2021.1211674-5817（2022）03-0207-06Construction Methods and Influencing Factors on Animal Model of SepsisLI XiaoYAN HaipengXIAO ZhenghuiSepsis is a common acute and critical illness, and its pathogenic mechanism is complex, often involving multiple organs and systems in the body. Various factors such as inflammatory response, immune dysfunction, and coagulation dysfunction are connected into an interconnected and mutually influencing network system, aggravating the severity of the disease. At present, the case fatality rate of sepsis is about 25%, which is a serious threat to human health. Establishing a stable and reliable experimental animal model of sepsis is an important means to understand the mechanism of host defense regulation in the early stage of infection, the mechanism of host response disorder in the stage of disease progression and to study the therapeutic effect of new therapeutic drugs. At present, there are many methods to establish animal models of sepsis, and there are many influencing factors. Therefore, this paper reviewed the preparation methods and influencing factors of animal models of sepsis, in order to provide some references for researchers to select suitable animal models.https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.121sepsisanimal modelscecal ligation and puncturemice |
| spellingShingle | LI Xiao YAN Haipeng XIAO Zhenghui Construction Methods and Influencing Factors on Animal Model of Sepsis Shiyan dongwu yu bijiao yixue sepsis animal models cecal ligation and puncture mice |
| title | Construction Methods and Influencing Factors on Animal Model of Sepsis |
| title_full | Construction Methods and Influencing Factors on Animal Model of Sepsis |
| title_fullStr | Construction Methods and Influencing Factors on Animal Model of Sepsis |
| title_full_unstemmed | Construction Methods and Influencing Factors on Animal Model of Sepsis |
| title_short | Construction Methods and Influencing Factors on Animal Model of Sepsis |
| title_sort | construction methods and influencing factors on animal model of sepsis |
| topic | sepsis animal models cecal ligation and puncture mice |
| url | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.121 |
| work_keys_str_mv | AT lixiao constructionmethodsandinfluencingfactorsonanimalmodelofsepsis AT yanhaipeng constructionmethodsandinfluencingfactorsonanimalmodelofsepsis AT xiaozhenghui constructionmethodsandinfluencingfactorsonanimalmodelofsepsis |