Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine
Colorectal cancer is one of the most important malignancies worldwide, with high incidence and mortality rates. Several studies have been conducted using two-dimensional cultured cell lines; however, these cells do not represent a study model of patient tumors very well. In recent years, advancement...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/5/695 |
| _version_ | 1797498651649507328 |
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| author | Takumi Kiwaki Hiroaki Kataoka |
| author_facet | Takumi Kiwaki Hiroaki Kataoka |
| author_sort | Takumi Kiwaki |
| collection | DOAJ |
| description | Colorectal cancer is one of the most important malignancies worldwide, with high incidence and mortality rates. Several studies have been conducted using two-dimensional cultured cell lines; however, these cells do not represent a study model of patient tumors very well. In recent years, advancements in three-dimensional culture methods have facilitated the establishment of patient-derived organoids, which have become indispensable for molecular biology-related studies of colorectal cancer. Patient-derived organoids are useful in both basic science and clinical practice; they can help predict the sensitivity of patients with cancer to chemotherapy and radiotherapy and provide the right treatment to the right patient. Regarding precision medicine, combining gene panel testing and organoid-based screening can increase the effectiveness of medical care. In this study, we review the development of three-dimensional culture methods and present the most recent information on the clinical application of patient-derived organoids. Moreover, we discuss the problems and future prospects of organoid-based personalized medicine. |
| first_indexed | 2024-03-10T03:36:24Z |
| format | Article |
| id | doaj.art-1d45725846b64671b1d9af7605cbbe5c |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T03:36:24Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-1d45725846b64671b1d9af7605cbbe5c2023-11-23T11:43:18ZengMDPI AGJournal of Personalized Medicine2075-44262022-04-0112569510.3390/jpm12050695Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized MedicineTakumi Kiwaki0Hiroaki Kataoka1Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Miyazaki 889-1692, JapanSection of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Miyazaki 889-1692, JapanColorectal cancer is one of the most important malignancies worldwide, with high incidence and mortality rates. Several studies have been conducted using two-dimensional cultured cell lines; however, these cells do not represent a study model of patient tumors very well. In recent years, advancements in three-dimensional culture methods have facilitated the establishment of patient-derived organoids, which have become indispensable for molecular biology-related studies of colorectal cancer. Patient-derived organoids are useful in both basic science and clinical practice; they can help predict the sensitivity of patients with cancer to chemotherapy and radiotherapy and provide the right treatment to the right patient. Regarding precision medicine, combining gene panel testing and organoid-based screening can increase the effectiveness of medical care. In this study, we review the development of three-dimensional culture methods and present the most recent information on the clinical application of patient-derived organoids. Moreover, we discuss the problems and future prospects of organoid-based personalized medicine.https://www.mdpi.com/2075-4426/12/5/695colorectal cancerpatient-derived organoids3D culturepersonalized medicine |
| spellingShingle | Takumi Kiwaki Hiroaki Kataoka Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine Journal of Personalized Medicine colorectal cancer patient-derived organoids 3D culture personalized medicine |
| title | Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine |
| title_full | Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine |
| title_fullStr | Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine |
| title_full_unstemmed | Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine |
| title_short | Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine |
| title_sort | patient derived organoids of colorectal cancer a useful tool for personalized medicine |
| topic | colorectal cancer patient-derived organoids 3D culture personalized medicine |
| url | https://www.mdpi.com/2075-4426/12/5/695 |
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