Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
Two new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytosp...
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MDPI AG
2020-09-01
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Online Access: | https://www.mdpi.com/1420-3049/25/18/4224 |
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author | Chengwen Wei Qin Deng Mengyu Sun Jing Xu |
author_facet | Chengwen Wei Qin Deng Mengyu Sun Jing Xu |
author_sort | Chengwen Wei |
collection | DOAJ |
description | Two new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytospora</i> sp. from the Chinese mangrove <i>Ceriops tagal</i>. Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound <b>2</b> displayed weak inhibitory activity against <i>Escherichia coli</i> GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds <b>4</b> and <b>5</b> displayed significant cytotoxicity against human cancer cell line HepG2 (IC<sub>50</sub> values of 5.98 ± 0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC<sub>50</sub> value of 43.50 ± 3.69 µM). |
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spelling | doaj.art-1d467807b18148de891e44bfaad1bcbc2023-11-20T13:46:15ZengMDPI AGMolecules1420-30492020-09-012518422410.3390/molecules25184224Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. Chengwen Wei0Qin Deng1Mengyu Sun2Jing Xu3Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaCollege of Horticulture and Landscape, Hainan University, Haikou 570228, ChinaKey Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaKey Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaTwo new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytospora</i> sp. from the Chinese mangrove <i>Ceriops tagal</i>. Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound <b>2</b> displayed weak inhibitory activity against <i>Escherichia coli</i> GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds <b>4</b> and <b>5</b> displayed significant cytotoxicity against human cancer cell line HepG2 (IC<sub>50</sub> values of 5.98 ± 0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC<sub>50</sub> value of 43.50 ± 3.69 µM).https://www.mdpi.com/1420-3049/25/18/4224<i>Cytospora</i> sp.polyketidesstructure identificationantimicrobial activitycytotoxicity |
spellingShingle | Chengwen Wei Qin Deng Mengyu Sun Jing Xu Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. Molecules <i>Cytospora</i> sp. polyketides structure identification antimicrobial activity cytotoxicity |
title | Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. |
title_full | Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. |
title_fullStr | Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. |
title_full_unstemmed | Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. |
title_short | Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. |
title_sort | cytospyrone and cytospomarin two new polyketides isolated from mangrove endophytic fungus i cytospora i sp |
topic | <i>Cytospora</i> sp. polyketides structure identification antimicrobial activity cytotoxicity |
url | https://www.mdpi.com/1420-3049/25/18/4224 |
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