Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.

Two new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytosp...

Full description

Bibliographic Details
Main Authors: Chengwen Wei, Qin Deng, Mengyu Sun, Jing Xu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/25/18/4224
_version_ 1797553629640523776
author Chengwen Wei
Qin Deng
Mengyu Sun
Jing Xu
author_facet Chengwen Wei
Qin Deng
Mengyu Sun
Jing Xu
author_sort Chengwen Wei
collection DOAJ
description Two new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytospora</i> sp. from the Chinese mangrove <i>Ceriops tagal</i>. Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound <b>2</b> displayed weak inhibitory activity against <i>Escherichia coli</i> GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds <b>4</b> and <b>5</b> displayed significant cytotoxicity against human cancer cell line HepG2 (IC<sub>50</sub> values of 5.98 ±  0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC<sub>50</sub> value of 43.50 ± 3.69 µM).
first_indexed 2024-03-10T16:19:16Z
format Article
id doaj.art-1d467807b18148de891e44bfaad1bcbc
institution Directory Open Access Journal
issn 1420-3049
language English
last_indexed 2024-03-10T16:19:16Z
publishDate 2020-09-01
publisher MDPI AG
record_format Article
series Molecules
spelling doaj.art-1d467807b18148de891e44bfaad1bcbc2023-11-20T13:46:15ZengMDPI AGMolecules1420-30492020-09-012518422410.3390/molecules25184224Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp. Chengwen Wei0Qin Deng1Mengyu Sun2Jing Xu3Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaCollege of Horticulture and Landscape, Hainan University, Haikou 570228, ChinaKey Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaKey Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, ChinaTwo new polyketides, cytospyrone (<b>1</b>), cytospomarin (<b>2</b>), together with three known metabolites dimethoxyphtalide (<b>3</b>), integracin A (<b>4</b>) and integracin B (<b>5</b>), were isolated from the culture of <i>Cytospora</i> sp. from the Chinese mangrove <i>Ceriops tagal</i>. Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound <b>2</b> displayed weak inhibitory activity against <i>Escherichia coli</i> GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds <b>4</b> and <b>5</b> displayed significant cytotoxicity against human cancer cell line HepG2 (IC<sub>50</sub> values of 5.98 ±  0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC<sub>50</sub> value of 43.50 ± 3.69 µM).https://www.mdpi.com/1420-3049/25/18/4224<i>Cytospora</i> sp.polyketidesstructure identificationantimicrobial activitycytotoxicity
spellingShingle Chengwen Wei
Qin Deng
Mengyu Sun
Jing Xu
Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
Molecules
<i>Cytospora</i> sp.
polyketides
structure identification
antimicrobial activity
cytotoxicity
title Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_full Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_fullStr Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_full_unstemmed Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_short Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, <i>Cytospora</i> sp.
title_sort cytospyrone and cytospomarin two new polyketides isolated from mangrove endophytic fungus i cytospora i sp
topic <i>Cytospora</i> sp.
polyketides
structure identification
antimicrobial activity
cytotoxicity
url https://www.mdpi.com/1420-3049/25/18/4224
work_keys_str_mv AT chengwenwei cytospyroneandcytospomarintwonewpolyketidesisolatedfrommangroveendophyticfungusicytosporaisp
AT qindeng cytospyroneandcytospomarintwonewpolyketidesisolatedfrommangroveendophyticfungusicytosporaisp
AT mengyusun cytospyroneandcytospomarintwonewpolyketidesisolatedfrommangroveendophyticfungusicytosporaisp
AT jingxu cytospyroneandcytospomarintwonewpolyketidesisolatedfrommangroveendophyticfungusicytosporaisp