Genetic Characterization of Feline Leukemia Virus from Florida Panthers
From 2002 through 2005, an outbreak of feline leukemia virus (FeLV) occurred in Florida panthers (Puma concolor coryi). Clinical signs included lymphadenopathy, anemia, septicemia, and weight loss; 5 panthers died. Not associated with FeLV outcome were the genetic heritage of the panthers (pure Flor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2008-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/14/2/07-0981_article |
| _version_ | 1818570879176540160 |
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| author | Meredith A. Brown Mark W. Cunningham Alfred L. Roca Jennifer L. Troyer Warren E. Johnson Stephen J. O’Brien |
| author_facet | Meredith A. Brown Mark W. Cunningham Alfred L. Roca Jennifer L. Troyer Warren E. Johnson Stephen J. O’Brien |
| author_sort | Meredith A. Brown |
| collection | DOAJ |
| description | From 2002 through 2005, an outbreak of feline leukemia virus (FeLV) occurred in Florida panthers (Puma concolor coryi). Clinical signs included lymphadenopathy, anemia, septicemia, and weight loss; 5 panthers died. Not associated with FeLV outcome were the genetic heritage of the panthers (pure Florida vs. Texas/Florida crosses) and co-infection with feline immunodeficiency virus. Genetic analysis of panther FeLV, designated FeLV-Pco, determined that the outbreak likely came from 1 cross-species transmission from a domestic cat. The FeLV-Pco virus was closely related to the domestic cat exogenous FeLV-A subgroup in lacking recombinant segments derived from endogenous FeLV. FeLV-Pco sequences were most similar to the well-characterized FeLV-945 strain, which is highly virulent and strongly pathogenic in domestic cats because of unique long terminal repeat and envelope sequences. These unique features may also account for the severity of the outbreak after cross-species transmission to the panther. |
| first_indexed | 2024-12-14T13:47:44Z |
| format | Article |
| id | doaj.art-1d46d1c86ca140b8abc0203f48e01930 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T13:47:44Z |
| publishDate | 2008-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-1d46d1c86ca140b8abc0203f48e019302022-12-21T22:59:15ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592008-02-0114225225910.3201/eid1402.070981Genetic Characterization of Feline Leukemia Virus from Florida PanthersMeredith A. BrownMark W. CunninghamAlfred L. RocaJennifer L. TroyerWarren E. JohnsonStephen J. O’BrienFrom 2002 through 2005, an outbreak of feline leukemia virus (FeLV) occurred in Florida panthers (Puma concolor coryi). Clinical signs included lymphadenopathy, anemia, septicemia, and weight loss; 5 panthers died. Not associated with FeLV outcome were the genetic heritage of the panthers (pure Florida vs. Texas/Florida crosses) and co-infection with feline immunodeficiency virus. Genetic analysis of panther FeLV, designated FeLV-Pco, determined that the outbreak likely came from 1 cross-species transmission from a domestic cat. The FeLV-Pco virus was closely related to the domestic cat exogenous FeLV-A subgroup in lacking recombinant segments derived from endogenous FeLV. FeLV-Pco sequences were most similar to the well-characterized FeLV-945 strain, which is highly virulent and strongly pathogenic in domestic cats because of unique long terminal repeat and envelope sequences. These unique features may also account for the severity of the outbreak after cross-species transmission to the panther.https://wwwnc.cdc.gov/eid/article/14/2/07-0981_articleCommunicable diseasesemergingleukemia virusfelinemolecular biologyimmunodeficiency virus |
| spellingShingle | Meredith A. Brown Mark W. Cunningham Alfred L. Roca Jennifer L. Troyer Warren E. Johnson Stephen J. O’Brien Genetic Characterization of Feline Leukemia Virus from Florida Panthers Emerging Infectious Diseases Communicable diseases emerging leukemia virus feline molecular biology immunodeficiency virus |
| title | Genetic Characterization of Feline Leukemia Virus from Florida Panthers |
| title_full | Genetic Characterization of Feline Leukemia Virus from Florida Panthers |
| title_fullStr | Genetic Characterization of Feline Leukemia Virus from Florida Panthers |
| title_full_unstemmed | Genetic Characterization of Feline Leukemia Virus from Florida Panthers |
| title_short | Genetic Characterization of Feline Leukemia Virus from Florida Panthers |
| title_sort | genetic characterization of feline leukemia virus from florida panthers |
| topic | Communicable diseases emerging leukemia virus feline molecular biology immunodeficiency virus |
| url | https://wwwnc.cdc.gov/eid/article/14/2/07-0981_article |
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