Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model
Mechanical stimulation, such as fluid-induced wall shear stress (WSS), is known that can influence the cellular behaviours. Therefore, in some tissue engineering experiments in vitro, mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and pathol...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Medicine in Novel Technology and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590093523000188 |
| _version_ | 1797790807352147968 |
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| author | Husham Ahmed Matthew Bedding-Tyrrell Davide Deganello Zhidao Xia Yi Xiong Feihu Zhao |
| author_facet | Husham Ahmed Matthew Bedding-Tyrrell Davide Deganello Zhidao Xia Yi Xiong Feihu Zhao |
| author_sort | Husham Ahmed |
| collection | DOAJ |
| description | Mechanical stimulation, such as fluid-induced wall shear stress (WSS), is known that can influence the cellular behaviours. Therefore, in some tissue engineering experiments in vitro, mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and pathology. In 3D cell culturing, porous scaffolds are used for housing the cells. It is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor (such as perfusion bioreactor). To calculate the WSS generated on cells within scaffolds, usually computational fluid dynamics (CFD) simulation is needed. However, the limitations of the computational method for WSS calculation are: (i) the high time cost of the CFD simulation (in particular for the highly irregular geometries); (ii) accessibility to the CFD model for some cell culturing experimentalists due to the knowledge gap. To address these limitations, this study aims to develop an empirical model for calculating the WSS based on scaffold permeability. This model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations. |
| first_indexed | 2024-03-13T02:09:47Z |
| format | Article |
| id | doaj.art-1d46e5e9773d41b59ebf1c5d21b3d463 |
| institution | Directory Open Access Journal |
| issn | 2590-0935 |
| language | English |
| last_indexed | 2024-03-13T02:09:47Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Novel Technology and Devices |
| spelling | doaj.art-1d46e5e9773d41b59ebf1c5d21b3d4632023-07-01T04:35:34ZengElsevierMedicine in Novel Technology and Devices2590-09352023-06-0118100223Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical modelHusham Ahmed0Matthew Bedding-Tyrrell1Davide Deganello2Zhidao Xia3Yi Xiong4Feihu Zhao5Zienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering, Faculty of Science & Engineering, Swansea University, Swansea, SA1 8EN, UKZienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering, Faculty of Science & Engineering, Swansea University, Swansea, SA1 8EN, UKWelsh Centre for Printing and Coating, Faculty of Science and Engineering, Swansea University, Swansea, SA1 8EN, UKCentre for Nanohealth, Swansea University Medical School and Faculty of Medicine, Health and Life Science, Swansea University, Swansea, SA3 5AU, UKSchool of System Design and Intelligent Manufacturing, Southern University of Science and Technology, Shenzhen, 518055, ChinaZienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering, Faculty of Science & Engineering, Swansea University, Swansea, SA1 8EN, UK; Corresponding author. Zienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering, Faculty of Science & Engineering, Swansea University, Bay Campus, Swansea, SA1 8EN, UK.Mechanical stimulation, such as fluid-induced wall shear stress (WSS), is known that can influence the cellular behaviours. Therefore, in some tissue engineering experiments in vitro, mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and pathology. In 3D cell culturing, porous scaffolds are used for housing the cells. It is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor (such as perfusion bioreactor). To calculate the WSS generated on cells within scaffolds, usually computational fluid dynamics (CFD) simulation is needed. However, the limitations of the computational method for WSS calculation are: (i) the high time cost of the CFD simulation (in particular for the highly irregular geometries); (ii) accessibility to the CFD model for some cell culturing experimentalists due to the knowledge gap. To address these limitations, this study aims to develop an empirical model for calculating the WSS based on scaffold permeability. This model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations.http://www.sciencedirect.com/science/article/pii/S2590093523000188Wall shear stressPermeabilityEmpirical modelTissue engineering scaffoldBioreactor |
| spellingShingle | Husham Ahmed Matthew Bedding-Tyrrell Davide Deganello Zhidao Xia Yi Xiong Feihu Zhao Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model Medicine in Novel Technology and Devices Wall shear stress Permeability Empirical model Tissue engineering scaffold Bioreactor |
| title | Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model |
| title_full | Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model |
| title_fullStr | Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model |
| title_full_unstemmed | Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model |
| title_short | Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model |
| title_sort | efficient calculation of fluid induced wall shear stress within tissue engineering scaffolds by an empirical model |
| topic | Wall shear stress Permeability Empirical model Tissue engineering scaffold Bioreactor |
| url | http://www.sciencedirect.com/science/article/pii/S2590093523000188 |
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