Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity.

Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity.

The known functions of telomerase in tumor cells include replenishing telomeric DNA and maintaining cell immortality. We have previously shown the existence of a negative correlation between human telomerase reverse transcriptase (hTERT) and radiosensitivity in tumor cells. Here we set out to elucid...

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Bibliographic Details
Main Authors: Wenbo Wang, Lei Yang, Liu Hu, Fen Li, Li Ren, Haijun Yu, Yu Liu, Ling Xia, Han Lei, Zhengkai Liao, Fuxiang Zhou, Conghua Xie, Yunfeng Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3669415?pdf=render

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