Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
We are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/7570 |
| _version_ | 1797446603597938688 |
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| author | Valeria Olguín Anyelo Durán Macarena Las Heras Juan Carlos Rubilar Francisco A. Cubillos Patricio Olguín Andrés D. Klein |
| author_facet | Valeria Olguín Anyelo Durán Macarena Las Heras Juan Carlos Rubilar Francisco A. Cubillos Patricio Olguín Andrés D. Klein |
| author_sort | Valeria Olguín |
| collection | DOAJ |
| description | We are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to the lack of variability, therapies are not always reproducible when treatments are translated to humans. Panels of already sequenced organisms are valuable tools for mimicking human phenotypic heterogeneities and gene mapping. This review summarizes the current knowledge of mouse, fly, and yeast panels with insightful applications for translational research. |
| first_indexed | 2024-03-09T13:42:58Z |
| format | Article |
| id | doaj.art-1d47646c69cb4a9680d6e43018ab860f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:42:58Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1d47646c69cb4a9680d6e43018ab860f2023-11-30T21:03:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314757010.3390/ijms23147570Genetic Background Matters: Population-Based Studies in Model Organisms for Translational ResearchValeria Olguín0Anyelo Durán1Macarena Las Heras2Juan Carlos Rubilar3Francisco A. Cubillos4Patricio Olguín5Andrés D. Klein6Centro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610658, ChileCentro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610658, ChileCentro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610658, ChileCentro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610658, ChileDepartamento de Biología, Santiago, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170022, ChileProgram in Human Genetics, Institute of Biomedical Sciences, Biomedical Neurosciences Institute, Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8380453, ChileCentro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610658, ChileWe are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to the lack of variability, therapies are not always reproducible when treatments are translated to humans. Panels of already sequenced organisms are valuable tools for mimicking human phenotypic heterogeneities and gene mapping. This review summarizes the current knowledge of mouse, fly, and yeast panels with insightful applications for translational research.https://www.mdpi.com/1422-0067/23/14/7570systems geneticsmouse<i>Drosophila</i><i>Saccharomyces cerevisiae</i>translational researchgenetic background |
| spellingShingle | Valeria Olguín Anyelo Durán Macarena Las Heras Juan Carlos Rubilar Francisco A. Cubillos Patricio Olguín Andrés D. Klein Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research International Journal of Molecular Sciences systems genetics mouse <i>Drosophila</i> <i>Saccharomyces cerevisiae</i> translational research genetic background |
| title | Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research |
| title_full | Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research |
| title_fullStr | Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research |
| title_full_unstemmed | Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research |
| title_short | Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research |
| title_sort | genetic background matters population based studies in model organisms for translational research |
| topic | systems genetics mouse <i>Drosophila</i> <i>Saccharomyces cerevisiae</i> translational research genetic background |
| url | https://www.mdpi.com/1422-0067/23/14/7570 |
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