Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen

Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen

Background & Aims: HBV persistence is maintained by both an episomal covalently closed circular (ccc)DNA reservoir and genomic integration of HBV DNA fragments. While cccDNA transcription is regulated by Cullin4A-DDB1-HBx-mediated degradation of the SMC5/6 complex, HBsAg expression from inte...

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Bibliographic Details
Main Authors: Bingqian Qu, Firat Nebioglu, Mila M. Leuthold, Yi Ni, Pascal Mutz, Jürgen Beneke, Holger Erfle, Florian W.R. Vondran, Ralf Bartenschlager, Stephan Urban
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:JHEP Reports
Subjects:
HBsAg
integrants
cccDNA
transcription
HBx
SMC6
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555922001239

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