National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study
Objective The objectives of this study were: (1) to describe burden of rheumatoid arthritis (RA) and trends from 1990 to 2019 using the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) data, (2) to describe age and sex differences in RA and (3) to compare Canada’s RA burden to that o...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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BMJ Publishing Group
2024-02-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/10/1/e003533.full |
| _version_ | 1797222020206821376 |
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| author | Om P Kurmi Lin Yang Nizal Sarrafzadegan Sanni Yaya Zulfiqar A Bhutta Zahid A Butt Barthelemy Kuate Defo Justin J Lang Andrew T Olagunju Jacek A Kopec Ranjani Somayaji Christopher J L Murray Dilaram Acharya Seyed-Mohammad Fereshtehnejad Al Artaman Ata Rafiee Diane Lacaille Daniel Adedayo Adeyinka Jeffrey J Hebert Marjan Mansourian Thirunavukkarasu Sathish Juwel Rana Amin Adibi Alice Xu Nejat Hassen Amani Alandejani Sophia Sidi Leah E Cahill Ihoghosa Osamuyi Iyamu Samiah Alam Promit Ananyo Chakraborty John Dube Ademola Joshua Itiola Negar Mousavi |
| author_facet | Om P Kurmi Lin Yang Nizal Sarrafzadegan Sanni Yaya Zulfiqar A Bhutta Zahid A Butt Barthelemy Kuate Defo Justin J Lang Andrew T Olagunju Jacek A Kopec Ranjani Somayaji Christopher J L Murray Dilaram Acharya Seyed-Mohammad Fereshtehnejad Al Artaman Ata Rafiee Diane Lacaille Daniel Adedayo Adeyinka Jeffrey J Hebert Marjan Mansourian Thirunavukkarasu Sathish Juwel Rana Amin Adibi Alice Xu Nejat Hassen Amani Alandejani Sophia Sidi Leah E Cahill Ihoghosa Osamuyi Iyamu Samiah Alam Promit Ananyo Chakraborty John Dube Ademola Joshua Itiola Negar Mousavi |
| collection | DOAJ |
| description | Objective The objectives of this study were: (1) to describe burden of rheumatoid arthritis (RA) and trends from 1990 to 2019 using the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) data, (2) to describe age and sex differences in RA and (3) to compare Canada’s RA burden to that of other countries.Methods Disease burden indicators included prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs) and disability-adjusted life-years (DALYs). GBD estimated fatal and non-fatal outcomes using published literature, survey data and health insurance claims. Data were analysed by Bayesian meta-regression, cause of death ensemble model and other statistical methods. DALYs for Canada were compared with DALYs of countries with similarly high Socio-Demographic Index values.Results In Canada, the RA prevalence rate increased by 27% between 1990 and 2019, mortality rate decreased by 27%, YLL rate decreased by 30%, YLD increased by 27% and DALY rate increased by 13%, all age standardised. The decline in RA mortality and YLL rates was especially pronounced after 2002. The disease burden was higher in females for all indicators, and DALY rates were higher among older age groups, peaking at age 75–79 years. Prevalence and DALYs were higher in Canada compared with global rates.Conclusion Trends in RA burden indicators over time and differences by age and sex have important implications for Canadian policy-makers, researchers and care providers. Early identification and management of RA in women may help reduce the overall burden of RA in Canada. |
| first_indexed | 2024-03-08T14:27:47Z |
| format | Article |
| id | doaj.art-1d485ded30584790a4e67137aa23f423 |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-04-24T13:14:41Z |
| publishDate | 2024-02-01 |
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| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-1d485ded30584790a4e67137aa23f4232024-04-04T22:55:08ZengBMJ Publishing GroupRMD Open2056-59332024-02-0110110.1136/rmdopen-2023-003533National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study Om P KurmiLin YangNizal Sarrafzadegan0Sanni YayaZulfiqar A Bhutta1Zahid A Butt2Barthelemy Kuate DefoJustin J Lang3Andrew T OlagunjuJacek A Kopec4Ranjani Somayaji5Christopher J L MurrayDilaram AcharyaSeyed-Mohammad FereshtehnejadAl ArtamanAta RafieeDiane Lacaille6Daniel Adedayo AdeyinkaJeffrey J HebertMarjan Mansourian7Thirunavukkarasu SathishJuwel Rana8Amin AdibiAlice Xu9Nejat Hassen10Amani Alandejani11Sophia Sidi12Leah E Cahill13Ihoghosa Osamuyi Iyamu14Samiah AlamPromit Ananyo ChakrabortyJohn DubeAdemola Joshua ItiolaNegar MousaviSchool of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, CanadaCenter of Excellence in Women and Child Health, Aga Khan University, Karachi, PakistanAl Shifa School of Public Health, Al-Shifa Trust Eye Hospital Rawalpindi, Rawalpindi, PakistanCentre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, Ontario, CanadaArthritis Research Canada, Vancouver, British Columbia, CanadaDepartment of Medicine, University of Washington, Seattle, Washington, USAArthritis Research Canada, Vancouver, British Columbia, CanadaPediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, CanadaSchool of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, CanadaArthritis Research Canada, Vancouver, British Columbia, CanadaSchool of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, CanadaSchool of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine, Dalhousie University, Halifax, Nova Scotia, CanadaSchool of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, CanadaObjective The objectives of this study were: (1) to describe burden of rheumatoid arthritis (RA) and trends from 1990 to 2019 using the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) data, (2) to describe age and sex differences in RA and (3) to compare Canada’s RA burden to that of other countries.Methods Disease burden indicators included prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs) and disability-adjusted life-years (DALYs). GBD estimated fatal and non-fatal outcomes using published literature, survey data and health insurance claims. Data were analysed by Bayesian meta-regression, cause of death ensemble model and other statistical methods. DALYs for Canada were compared with DALYs of countries with similarly high Socio-Demographic Index values.Results In Canada, the RA prevalence rate increased by 27% between 1990 and 2019, mortality rate decreased by 27%, YLL rate decreased by 30%, YLD increased by 27% and DALY rate increased by 13%, all age standardised. The decline in RA mortality and YLL rates was especially pronounced after 2002. The disease burden was higher in females for all indicators, and DALY rates were higher among older age groups, peaking at age 75–79 years. Prevalence and DALYs were higher in Canada compared with global rates.Conclusion Trends in RA burden indicators over time and differences by age and sex have important implications for Canadian policy-makers, researchers and care providers. Early identification and management of RA in women may help reduce the overall burden of RA in Canada.https://rmdopen.bmj.com/content/10/1/e003533.full |
| spellingShingle | Om P Kurmi Lin Yang Nizal Sarrafzadegan Sanni Yaya Zulfiqar A Bhutta Zahid A Butt Barthelemy Kuate Defo Justin J Lang Andrew T Olagunju Jacek A Kopec Ranjani Somayaji Christopher J L Murray Dilaram Acharya Seyed-Mohammad Fereshtehnejad Al Artaman Ata Rafiee Diane Lacaille Daniel Adedayo Adeyinka Jeffrey J Hebert Marjan Mansourian Thirunavukkarasu Sathish Juwel Rana Amin Adibi Alice Xu Nejat Hassen Amani Alandejani Sophia Sidi Leah E Cahill Ihoghosa Osamuyi Iyamu Samiah Alam Promit Ananyo Chakraborty John Dube Ademola Joshua Itiola Negar Mousavi National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study RMD Open |
| title | National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study |
| title_full | National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study |
| title_fullStr | National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study |
| title_full_unstemmed | National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study |
| title_short | National burden of rheumatoid arthritis in Canada, 1990–2019: findings from the Global Burden of Disease Study 2019 – a GBD collaborator-led study |
| title_sort | national burden of rheumatoid arthritis in canada 1990 2019 findings from the global burden of disease study 2019 a gbd collaborator led study |
| url | https://rmdopen.bmj.com/content/10/1/e003533.full |
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