Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study]
Background: Several industrial products [such as paints, cosmetics, and petrol] contained metals like lead [Pb], which are harmful to people. The reproductive organs are the primary organs affected by heavy metal toxicity through the production of oxidative stress. Selenium and curcumin could help t...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Al-Azhar University, Faculty of Medicine (Damietta)
2023-02-01
|
| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_297279_6584f2ed9b54c687eab97806d31aa16a.pdf |
| _version_ | 1797364416968130560 |
|---|---|
| author | Alsayed Abdel Hady Ezz-Eldin Abd-Allah Nahed Emam Alaa Eldein El-Sagheer Amr Younes Ahmed Abdel Monsef Amany Wahb Ahmed Moustafa Mokhtar Abo-Elfotoh E. Tayee Noha Shawky |
| author_facet | Alsayed Abdel Hady Ezz-Eldin Abd-Allah Nahed Emam Alaa Eldein El-Sagheer Amr Younes Ahmed Abdel Monsef Amany Wahb Ahmed Moustafa Mokhtar Abo-Elfotoh E. Tayee Noha Shawky |
| author_sort | Alsayed Abdel Hady |
| collection | DOAJ |
| description | Background: Several industrial products [such as paints, cosmetics, and petrol] contained metals like lead [Pb], which are harmful to people. The reproductive organs are the primary organs affected by heavy metal toxicity through the production of oxidative stress. Selenium and curcumin could help to counteract this toxicity.Aim of the work: We investigated the possible role of Selenium or curcumin in improving the testicular toxicity caused by the intake of Lead orally in albino rats.Materials and Methods: 40 adult male albino rats were selected and unsystematically separated into 4 groups [10 rats/each] included: Group 1: control group; Group 2: Pb-exposed group; Group 3: Pb plus Selenium and Group 4: Pb plus Curcumin. Blood samples were collected for examination of serum biochemical parameters, serum Testosterone, LH, FSH levels, Total Anti-oxidant Capacity [TAC], testicular tissue oxidative stress parameters and testicular histology were evaluated.Results: Oral administration of Pb to rats for 4 weeks disturbs the testicular structure and function with a significant increase in the oxidative stress enzymes, deposition of collagen fibers and anticaspase-3 in the testis. While, administration of either Selenium or Curcumin with Pb-exposure induced significant improvement of all the testicular changes.Conclusion: Chronic lead exposure causes deteriorating changes in the testicular structures and functions which could be improved by oral intake of either Selenium or Curcumin by their antioxidant, antifibrotic, and antiapoptotic properties. |
| first_indexed | 2024-03-08T16:35:00Z |
| format | Article |
| id | doaj.art-1d48cac9b76449278e2b429915b07084 |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-03-08T16:35:00Z |
| publishDate | 2023-02-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-1d48cac9b76449278e2b429915b070842024-01-05T19:36:12ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802023-02-01523045305310.21608/ijma.2023.203141.1659297279Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study]Alsayed Abdel Hady0Ezz-Eldin Abd-Allah1Nahed Emam2Alaa Eldein El-Sagheer3Amr Younes4Ahmed Abdel Monsef5Amany Wahb6Ahmed Moustafa7Mokhtar Abo-Elfotoh8E. Tayee9Noha Shawky10Department of Anatomy, Faculty of Medicine, Helwan University, Helwan, Egypt.Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, EgyptDepartment of Zoology, Faculty of Science, Al Arish University, North Sinai, EgyptDepartment of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Anatomy and Embryology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, EgyptDepartment of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Helwan University, Helwan, EgyptDepartment of Medical Biochemistry, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, EgyptDepartment of Clinical Pharmacology, Faculty of Medicine, Helwan University, Helwan, Egypt.Department of Medical Physiology, Faculty of Medicine, Helwan University, Helwan, EgyptBackground: Several industrial products [such as paints, cosmetics, and petrol] contained metals like lead [Pb], which are harmful to people. The reproductive organs are the primary organs affected by heavy metal toxicity through the production of oxidative stress. Selenium and curcumin could help to counteract this toxicity.Aim of the work: We investigated the possible role of Selenium or curcumin in improving the testicular toxicity caused by the intake of Lead orally in albino rats.Materials and Methods: 40 adult male albino rats were selected and unsystematically separated into 4 groups [10 rats/each] included: Group 1: control group; Group 2: Pb-exposed group; Group 3: Pb plus Selenium and Group 4: Pb plus Curcumin. Blood samples were collected for examination of serum biochemical parameters, serum Testosterone, LH, FSH levels, Total Anti-oxidant Capacity [TAC], testicular tissue oxidative stress parameters and testicular histology were evaluated.Results: Oral administration of Pb to rats for 4 weeks disturbs the testicular structure and function with a significant increase in the oxidative stress enzymes, deposition of collagen fibers and anticaspase-3 in the testis. While, administration of either Selenium or Curcumin with Pb-exposure induced significant improvement of all the testicular changes.Conclusion: Chronic lead exposure causes deteriorating changes in the testicular structures and functions which could be improved by oral intake of either Selenium or Curcumin by their antioxidant, antifibrotic, and antiapoptotic properties.https://ijma.journals.ekb.eg/article_297279_6584f2ed9b54c687eab97806d31aa16a.pdfleadtestisoxidative stressseleniumcurcumin |
| spellingShingle | Alsayed Abdel Hady Ezz-Eldin Abd-Allah Nahed Emam Alaa Eldein El-Sagheer Amr Younes Ahmed Abdel Monsef Amany Wahb Ahmed Moustafa Mokhtar Abo-Elfotoh E. Tayee Noha Shawky Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study] International Journal of Medical Arts lead testis oxidative stress selenium curcumin |
| title | Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study] |
| title_full | Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study] |
| title_fullStr | Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study] |
| title_full_unstemmed | Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study] |
| title_short | Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study] |
| title_sort | protective effects of curcumin and selenium on testicular toxicity induced by lead acetate in adult male albino rats structural and biochemical study |
| topic | lead testis oxidative stress selenium curcumin |
| url | https://ijma.journals.ekb.eg/article_297279_6584f2ed9b54c687eab97806d31aa16a.pdf |
| work_keys_str_mv | AT alsayedabdelhady protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT ezzeldinabdallah protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT nahedemam protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT alaaeldeinelsagheer protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT amryounes protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT ahmedabdelmonsef protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT amanywahb protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT ahmedmoustafa protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT mokhtaraboelfotoh protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT etayee protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy AT nohashawky protectiveeffectsofcurcuminandseleniumontesticulartoxicityinducedbyleadacetateinadultmalealbinoratsstructuralandbiochemicalstudy |