Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M

Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M

Aberrant inflammation is a hallmark of inflammatory bowel disease (IBD) and colorectal cancer. IRAK-M is a critical negative regulator of TLR signaling and overzealous inflammation. Here we utilize data from human studies and Irak-m−/− mice to elucidate the role of IRAK-M in the modulation of gastro...

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Bibliographic Details
Main Authors: Daniel E. Rothschild, Yao Zhang, Na Diao, Christina K. Lee, Keqiang Chen, Clayton C. Caswell, Daniel J. Slade, Richard F. Helm, Tanya LeRoith, Liwu Li, Irving C. Allen
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:EBioMedicine
Subjects:
Colitis
Colitis associated cancer
GALT
Inflammatory bowel disease
IRAK-M
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416305564

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