Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism

Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism

Abstract Background Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found. No pharmaceutical treatment is available today and recurrence after surgical extraction occurs. We investigated possible TL...

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Bibliographic Details
Main Authors: Matthias Schürmann, Felix Oppel, Senyao Shao, Verena Volland-Thurn, Christian Kaltschmidt, Barbara Kaltschmidt, Lars-Uwe Scholtz, Holger Sudhoff
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell Communication and Signaling
Subjects:
Cholesteatoma
Inflammation
TLR4
Stem cells
Cholesteatoma recurrence
Online Access:https://doi.org/10.1186/s12964-020-00690-y

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