Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization

Influenza virus alters glycosylation patterns on its surface exposed glycoproteins to evade host adaptive immune responses. The viral hemagglutinin (HA), in particular the H3 subtype, has increased its overall surface glycosylation since its introduction in 1968. We previously showed that modulating...

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Bibliographic Details
Main Authors: Dana N. Thornlow, Andrew N. Macintyre, Thomas H. Oguin, Amelia B. Karlsson, Erica L. Stover, Heather E. Lynch, Gregory D. Sempowski, Aaron G. Schmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
influenza
hemagglutinin
glycans
immunogen design
adaptive immunity
B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.737973/full

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