De novo peptide design and experimental validation of histone methyltransferase inhibitors.

De novo peptide design and experimental validation of histone methyltransferase inhibitors.

Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA–protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2) maintains gene repres...

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Bibliographic Details
Main Authors: James Smadbeck, Meghan B Peterson, Barry M Zee, Shivani Garapaty, Aashna Mago, Christina Lee, Athanassios Giannis, Patrick Trojer, Benjamin A Garcia, Christodoulos A Floudas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3989331?pdf=render

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