DNA Copy Number Aberrations and Expression of ABC Transporter Genes in Breast Tumour: Correlation with the Effect of Neoadjuvant Chemotherapy and Prognosis of the Disease

DNA Copy Number Aberrations and Expression of ABC Transporter Genes in Breast Tumour: Correlation with the Effect of Neoadjuvant Chemotherapy and Prognosis of the Disease

One of the important reasons for the ineffectiveness of chemotherapy in breast cancer (BC) is considered to be the formation of a multidrug resistance phenotype in tumour cells, which is caused by the expression of energy-dependent ABC transporters. The aim of this work was to assess chromosomal abe...

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Bibliographic Details
Main Authors: Matvey M. Tsyganov, Marina K. Ibragimova, Kseniya A. Gaptulbarova, Irina A. Tsydenova, Daria S. Dolgasheva, Evgeniy Y. Garbukov, Anastasia A. Frolova, Elena M. Slonimskaya, Nikolai V. Litvyakov
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
ABC transporters
gene expression
DNA copy number aberrations
neoadjuvant chemotherapy
prognosis
Online Access:https://www.mdpi.com/1999-4923/14/5/948

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