The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery stories
Abstract Preface by Prof. Titia de Lange, Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA The 19th Annual Wiley Prize in Biomedical Sciences celebrated a breakthrough in cell biology: how membrane‐less cellular compartments are formed. The existence of m...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-10-01
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| Series: | Natural Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ntls.20210091 |
| _version_ | 1811250279036747776 |
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| author | Clifford Brangwynne Anthony A. Hyman Michael K. Rosen |
| author_facet | Clifford Brangwynne Anthony A. Hyman Michael K. Rosen |
| author_sort | Clifford Brangwynne |
| collection | DOAJ |
| description | Abstract Preface by Prof. Titia de Lange, Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA The 19th Annual Wiley Prize in Biomedical Sciences celebrated a breakthrough in cell biology: how membrane‐less cellular compartments are formed. The existence of membrane‐less organelles, often called bodies or puncta, has been known for a long time, but what exactly they represented and how they were formed was not known. This problem was solved by a physicist, Clifford Brangwynne, a cell biologist, Anthony Hyman, and a chemist, Michael Rosen. Each, synergistically, made groundbreaking contributions to the discovery that membrane‐less organelles are liquid–liquid phase‐separated entities. The two independent discoveries leading to the principle that multivalent low‐affinity interactions between selected sets of macromolecules, some containing intrinsically disordered regions, formed a molecular condensate with unique dynamic properties, gave birth to the large, blossoming field of biomolecular condensates. The implications of those findings have influenced almost all further research of intracellular processes, including RAS signaling, immune synapses, DNA repair, transcriptional activation, and the functions of nuclear pores, the nucleolus and centrosomes. In this perspective article, the laureates of the award take us on their personal and professional trip that led to their scientific discoveries. Their stories are a celebration of the interdisciplinary essence of Natural Sciences and the potential unlocked when scientists from different fields work together to solve mysteries. |
| first_indexed | 2024-04-12T16:02:14Z |
| format | Article |
| id | doaj.art-1d4e4a33d3154b5280810bf8f49e0c25 |
| institution | Directory Open Access Journal |
| issn | 2698-6248 |
| language | English |
| last_indexed | 2024-04-12T16:02:14Z |
| publishDate | 2022-10-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Natural Sciences |
| spelling | doaj.art-1d4e4a33d3154b5280810bf8f49e0c252022-12-22T03:26:10ZengWiley-VCHNatural Sciences2698-62482022-10-0124n/an/a10.1002/ntls.20210091The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery storiesClifford Brangwynne0Anthony A. Hyman1Michael K. Rosen2Department of Chemical and Biological Engineering Princeton University Princeton New Jersey USAMax Planck Institute of Cell Biology and Genetics Dresden GermanyDepartment of Biophysics Howard Hughes Medical Institute, UT Southwestern Medical Center Dallas Texas USAAbstract Preface by Prof. Titia de Lange, Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA The 19th Annual Wiley Prize in Biomedical Sciences celebrated a breakthrough in cell biology: how membrane‐less cellular compartments are formed. The existence of membrane‐less organelles, often called bodies or puncta, has been known for a long time, but what exactly they represented and how they were formed was not known. This problem was solved by a physicist, Clifford Brangwynne, a cell biologist, Anthony Hyman, and a chemist, Michael Rosen. Each, synergistically, made groundbreaking contributions to the discovery that membrane‐less organelles are liquid–liquid phase‐separated entities. The two independent discoveries leading to the principle that multivalent low‐affinity interactions between selected sets of macromolecules, some containing intrinsically disordered regions, formed a molecular condensate with unique dynamic properties, gave birth to the large, blossoming field of biomolecular condensates. The implications of those findings have influenced almost all further research of intracellular processes, including RAS signaling, immune synapses, DNA repair, transcriptional activation, and the functions of nuclear pores, the nucleolus and centrosomes. In this perspective article, the laureates of the award take us on their personal and professional trip that led to their scientific discoveries. Their stories are a celebration of the interdisciplinary essence of Natural Sciences and the potential unlocked when scientists from different fields work together to solve mysteries.https://doi.org/10.1002/ntls.20210091biomolecular condensateliquid‐liquid phase separationmultivalencyp bodyWiley Prize |
| spellingShingle | Clifford Brangwynne Anthony A. Hyman Michael K. Rosen The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery stories Natural Sciences biomolecular condensate liquid‐liquid phase separation multivalency p body Wiley Prize |
| title | The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery stories |
| title_full | The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery stories |
| title_fullStr | The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery stories |
| title_full_unstemmed | The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery stories |
| title_short | The path to condensates—19th Wiley Prize in Biomedical Sciences laureates share their discovery stories |
| title_sort | path to condensates 19th wiley prize in biomedical sciences laureates share their discovery stories |
| topic | biomolecular condensate liquid‐liquid phase separation multivalency p body Wiley Prize |
| url | https://doi.org/10.1002/ntls.20210091 |
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