FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity

FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity

Lactate dehydrogenase A (LDHA) mediates interconversion of pyruvate and lactate, and increased lactate turnover is exhibited by malignant and infected immune cells. Hypoxic lung granuloma in Mycobacterium tuberculosis-infected animals present elevated levels of Ldha and lactate. Such alterations in...

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Bibliographic Details
Main Authors: Gopinath Krishnamoorthy, Peggy Kaiser, Ulrike Abu Abed, January Weiner, Pedro Moura-Alves, Volker Brinkmann, Stefan H. E. Kaufmann
Format: Article
Language:English
Published: The Company of Biologists 2020-03-01
Series:Disease Models & Mechanisms
Subjects:
glycolysis
lactate dehydrogenase a
fx11
mycobacterium tuberculosis
granuloma
hypoxia
immunometabolism
host-directed therapy
Online Access:http://dmm.biologists.org/content/13/3/dmm041954

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