Evolution of Highly Biocompatible and Thermally Stable YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> Upconversion Mesoporous Hollow Nanospheriods as Drug Carriers for Therapeutic Applications
In recent times, upconversion nanomaterials with mesoporous hollow structures have gained significant interest as a prospective nano-platform for cancer imaging and therapeutic applications. In this study, we report a highly biocompatible YVO<sub>4</sub>:1Er<sup>3+</sup>/10Yb...
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MDPI AG
2022-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/15/2520 |
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| author | Eluri Pavitra Hoomin Lee Seung Kyu Hwang Jin Young Park Young-Kyu Han Ganji Seeta Rama Raju Yun Suk Huh |
| author_facet | Eluri Pavitra Hoomin Lee Seung Kyu Hwang Jin Young Park Young-Kyu Han Ganji Seeta Rama Raju Yun Suk Huh |
| author_sort | Eluri Pavitra |
| collection | DOAJ |
| description | In recent times, upconversion nanomaterials with mesoporous hollow structures have gained significant interest as a prospective nano-platform for cancer imaging and therapeutic applications. In this study, we report a highly biocompatible YVO<sub>4</sub>:1Er<sup>3+</sup>/10Yb<sup>3+</sup> upconversion mesoporous hollow nanospheriods (YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs) by a facile and rapid self-sacrificing template method. The Rietveld analysis confirmed their pure phase of tetragonal zircon structure. Nitrogen adsorption–desorption isotherms revealed the mesoporous nature of these UC-MHNSPs and the surface area is found to be ~87.46 m<sup>2</sup>/g. Under near-infrared excitation (980 nm), YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs showed interesting color tunability from red to green emission. Initially (at 0.4 W), energy back transfer from Er<sup>3+</sup> to Yb<sup>3+</sup> ions leads to the strong red emission. Whereas at high pump powers (1 W), a fine green emission is observed due to the dominant three-photon excitation process and traditional energy transfer route from Er<sup>3+</sup> to Yb<sup>3+</sup> ions. The bright red light from the membrane of HeLa cells confirmed the effective cellular uptake of YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs. The resonant decrease in cell viability on increasing the concentration of curcumin conjugated YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs established their excellent antitumor activity. Therefore, the acquired results indicate that these YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs are promising drug carriers for bioimaging and various therapeutic applications. |
| first_indexed | 2024-03-09T12:19:34Z |
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| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T12:19:34Z |
| publishDate | 2022-07-01 |
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| spelling | doaj.art-1d4e969cd8c442e29b77b16e364c7d052023-11-30T22:41:52ZengMDPI AGNanomaterials2079-49912022-07-011215252010.3390/nano12152520Evolution of Highly Biocompatible and Thermally Stable YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> Upconversion Mesoporous Hollow Nanospheriods as Drug Carriers for Therapeutic ApplicationsEluri Pavitra0Hoomin Lee1Seung Kyu Hwang2Jin Young Park3Young-Kyu Han4Ganji Seeta Rama Raju5Yun Suk Huh6Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, Incheon 22212, KoreaDepartment of Electrical, Electronics and Software Engineering, Pukyong National University, Yongdang Campus, Busan 48547, KoreaDepartment of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 04620, KoreaDepartment of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 04620, KoreaDepartment of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, Incheon 22212, KoreaIn recent times, upconversion nanomaterials with mesoporous hollow structures have gained significant interest as a prospective nano-platform for cancer imaging and therapeutic applications. In this study, we report a highly biocompatible YVO<sub>4</sub>:1Er<sup>3+</sup>/10Yb<sup>3+</sup> upconversion mesoporous hollow nanospheriods (YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs) by a facile and rapid self-sacrificing template method. The Rietveld analysis confirmed their pure phase of tetragonal zircon structure. Nitrogen adsorption–desorption isotherms revealed the mesoporous nature of these UC-MHNSPs and the surface area is found to be ~87.46 m<sup>2</sup>/g. Under near-infrared excitation (980 nm), YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs showed interesting color tunability from red to green emission. Initially (at 0.4 W), energy back transfer from Er<sup>3+</sup> to Yb<sup>3+</sup> ions leads to the strong red emission. Whereas at high pump powers (1 W), a fine green emission is observed due to the dominant three-photon excitation process and traditional energy transfer route from Er<sup>3+</sup> to Yb<sup>3+</sup> ions. The bright red light from the membrane of HeLa cells confirmed the effective cellular uptake of YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs. The resonant decrease in cell viability on increasing the concentration of curcumin conjugated YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs established their excellent antitumor activity. Therefore, the acquired results indicate that these YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> UC-MHNSPs are promising drug carriers for bioimaging and various therapeutic applications.https://www.mdpi.com/2079-4991/12/15/2520mesoporous hollow nanospheriodsUC luminescencecolor tunabilityfluorescence imagingantitumor activity |
| spellingShingle | Eluri Pavitra Hoomin Lee Seung Kyu Hwang Jin Young Park Young-Kyu Han Ganji Seeta Rama Raju Yun Suk Huh Evolution of Highly Biocompatible and Thermally Stable YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> Upconversion Mesoporous Hollow Nanospheriods as Drug Carriers for Therapeutic Applications Nanomaterials mesoporous hollow nanospheriods UC luminescence color tunability fluorescence imaging antitumor activity |
| title | Evolution of Highly Biocompatible and Thermally Stable YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> Upconversion Mesoporous Hollow Nanospheriods as Drug Carriers for Therapeutic Applications |
| title_full | Evolution of Highly Biocompatible and Thermally Stable YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> Upconversion Mesoporous Hollow Nanospheriods as Drug Carriers for Therapeutic Applications |
| title_fullStr | Evolution of Highly Biocompatible and Thermally Stable YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> Upconversion Mesoporous Hollow Nanospheriods as Drug Carriers for Therapeutic Applications |
| title_full_unstemmed | Evolution of Highly Biocompatible and Thermally Stable YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> Upconversion Mesoporous Hollow Nanospheriods as Drug Carriers for Therapeutic Applications |
| title_short | Evolution of Highly Biocompatible and Thermally Stable YVO<sub>4</sub>:Er<sup>3+</sup>/Yb<sup>3+</sup> Upconversion Mesoporous Hollow Nanospheriods as Drug Carriers for Therapeutic Applications |
| title_sort | evolution of highly biocompatible and thermally stable yvo sub 4 sub er sup 3 sup yb sup 3 sup upconversion mesoporous hollow nanospheriods as drug carriers for therapeutic applications |
| topic | mesoporous hollow nanospheriods UC luminescence color tunability fluorescence imaging antitumor activity |
| url | https://www.mdpi.com/2079-4991/12/15/2520 |
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