A rhesus macaque model of Asian-lineage Zika virus infection
Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12204 |
| _version_ | 1819040231934918656 |
|---|---|
| author | Dawn M. Dudley Matthew T. Aliota Emma L. Mohr Andrea M. Weiler Gabrielle Lehrer-Brey Kim L. Weisgrau Mariel S. Mohns Meghan E. Breitbach Mustafa N. Rasheed Christina M. Newman Dane D. Gellerup Louise H. Moncla Jennifer Post Nancy Schultz-Darken Michele L. Schotzko Jennifer M. Hayes Josh A. Eudailey M. Anthony Moody Sallie R. Permar Shelby L. O’Connor Eva G. Rakasz Heather A. Simmons Saverio Capuano Thaddeus G. Golos Jorge E. Osorio Thomas C. Friedrich David H. O’Connor |
| author_facet | Dawn M. Dudley Matthew T. Aliota Emma L. Mohr Andrea M. Weiler Gabrielle Lehrer-Brey Kim L. Weisgrau Mariel S. Mohns Meghan E. Breitbach Mustafa N. Rasheed Christina M. Newman Dane D. Gellerup Louise H. Moncla Jennifer Post Nancy Schultz-Darken Michele L. Schotzko Jennifer M. Hayes Josh A. Eudailey M. Anthony Moody Sallie R. Permar Shelby L. O’Connor Eva G. Rakasz Heather A. Simmons Saverio Capuano Thaddeus G. Golos Jorge E. Osorio Thomas C. Friedrich David H. O’Connor |
| author_sort | Dawn M. Dudley |
| collection | DOAJ |
| description | Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis. |
| first_indexed | 2024-12-21T09:05:49Z |
| format | Article |
| id | doaj.art-1d500df450f942ebbe6246e44f2a96d7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:05:49Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1d500df450f942ebbe6246e44f2a96d72022-12-21T19:09:20ZengNature PortfolioNature Communications2041-17232016-06-01711910.1038/ncomms12204A rhesus macaque model of Asian-lineage Zika virus infectionDawn M. Dudley0Matthew T. Aliota1Emma L. Mohr2Andrea M. Weiler3Gabrielle Lehrer-Brey4Kim L. Weisgrau5Mariel S. Mohns6Meghan E. Breitbach7Mustafa N. Rasheed8Christina M. Newman9Dane D. Gellerup10Louise H. Moncla11Jennifer Post12Nancy Schultz-Darken13Michele L. Schotzko14Jennifer M. Hayes15Josh A. Eudailey16M. Anthony Moody17Sallie R. Permar18Shelby L. O’Connor19Eva G. Rakasz20Heather A. Simmons21Saverio Capuano22Thaddeus G. Golos23Jorge E. Osorio24Thomas C. Friedrich25David H. O’Connor26Department of Pathology and Laboratory Medicine, University of Wisconsin-MadisonDepartment of Pathobiological Sciences, University of Wisconsin-MadisonDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonDepartment of Pathology and Laboratory Medicine, University of Wisconsin-MadisonDepartment of Pathology and Laboratory Medicine, University of Wisconsin-MadisonDepartment of Pathology and Laboratory Medicine, University of Wisconsin-MadisonDepartment of Pathology and Laboratory Medicine, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonDepartment of Pathology and Laboratory Medicine, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonDepartment of Pediatrics and Human Vaccine Institute, Duke University Medical CenterDepartment of Pediatrics and Human Vaccine Institute, Duke University Medical CenterDepartment of Pediatrics and Human Vaccine Institute, Duke University Medical CenterDepartment of Pathology and Laboratory Medicine, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonWisconsin National Primate Research Center, University of Wisconsin-MadisonDepartment of Pathobiological Sciences, University of Wisconsin-MadisonDepartment of Pathobiological Sciences, University of Wisconsin-MadisonDepartment of Pathology and Laboratory Medicine, University of Wisconsin-MadisonAnimal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis.https://doi.org/10.1038/ncomms12204 |
| spellingShingle | Dawn M. Dudley Matthew T. Aliota Emma L. Mohr Andrea M. Weiler Gabrielle Lehrer-Brey Kim L. Weisgrau Mariel S. Mohns Meghan E. Breitbach Mustafa N. Rasheed Christina M. Newman Dane D. Gellerup Louise H. Moncla Jennifer Post Nancy Schultz-Darken Michele L. Schotzko Jennifer M. Hayes Josh A. Eudailey M. Anthony Moody Sallie R. Permar Shelby L. O’Connor Eva G. Rakasz Heather A. Simmons Saverio Capuano Thaddeus G. Golos Jorge E. Osorio Thomas C. Friedrich David H. O’Connor A rhesus macaque model of Asian-lineage Zika virus infection Nature Communications |
| title | A rhesus macaque model of Asian-lineage Zika virus infection |
| title_full | A rhesus macaque model of Asian-lineage Zika virus infection |
| title_fullStr | A rhesus macaque model of Asian-lineage Zika virus infection |
| title_full_unstemmed | A rhesus macaque model of Asian-lineage Zika virus infection |
| title_short | A rhesus macaque model of Asian-lineage Zika virus infection |
| title_sort | rhesus macaque model of asian lineage zika virus infection |
| url | https://doi.org/10.1038/ncomms12204 |
| work_keys_str_mv | AT dawnmdudley arhesusmacaquemodelofasianlineagezikavirusinfection AT matthewtaliota arhesusmacaquemodelofasianlineagezikavirusinfection AT emmalmohr arhesusmacaquemodelofasianlineagezikavirusinfection AT andreamweiler arhesusmacaquemodelofasianlineagezikavirusinfection AT gabriellelehrerbrey arhesusmacaquemodelofasianlineagezikavirusinfection AT kimlweisgrau arhesusmacaquemodelofasianlineagezikavirusinfection AT marielsmohns arhesusmacaquemodelofasianlineagezikavirusinfection AT meghanebreitbach arhesusmacaquemodelofasianlineagezikavirusinfection AT mustafanrasheed arhesusmacaquemodelofasianlineagezikavirusinfection AT christinamnewman arhesusmacaquemodelofasianlineagezikavirusinfection AT danedgellerup arhesusmacaquemodelofasianlineagezikavirusinfection AT louisehmoncla arhesusmacaquemodelofasianlineagezikavirusinfection AT jenniferpost arhesusmacaquemodelofasianlineagezikavirusinfection AT nancyschultzdarken arhesusmacaquemodelofasianlineagezikavirusinfection AT michelelschotzko arhesusmacaquemodelofasianlineagezikavirusinfection AT jennifermhayes arhesusmacaquemodelofasianlineagezikavirusinfection AT joshaeudailey arhesusmacaquemodelofasianlineagezikavirusinfection AT manthonymoody arhesusmacaquemodelofasianlineagezikavirusinfection AT sallierpermar arhesusmacaquemodelofasianlineagezikavirusinfection AT shelbyloconnor arhesusmacaquemodelofasianlineagezikavirusinfection AT evagrakasz arhesusmacaquemodelofasianlineagezikavirusinfection AT heatherasimmons arhesusmacaquemodelofasianlineagezikavirusinfection AT saveriocapuano arhesusmacaquemodelofasianlineagezikavirusinfection AT thaddeusggolos arhesusmacaquemodelofasianlineagezikavirusinfection AT jorgeeosorio arhesusmacaquemodelofasianlineagezikavirusinfection AT thomascfriedrich arhesusmacaquemodelofasianlineagezikavirusinfection AT davidhoconnor arhesusmacaquemodelofasianlineagezikavirusinfection AT dawnmdudley rhesusmacaquemodelofasianlineagezikavirusinfection AT matthewtaliota rhesusmacaquemodelofasianlineagezikavirusinfection AT emmalmohr rhesusmacaquemodelofasianlineagezikavirusinfection AT andreamweiler rhesusmacaquemodelofasianlineagezikavirusinfection AT gabriellelehrerbrey rhesusmacaquemodelofasianlineagezikavirusinfection AT kimlweisgrau rhesusmacaquemodelofasianlineagezikavirusinfection AT marielsmohns rhesusmacaquemodelofasianlineagezikavirusinfection AT meghanebreitbach rhesusmacaquemodelofasianlineagezikavirusinfection AT mustafanrasheed rhesusmacaquemodelofasianlineagezikavirusinfection AT christinamnewman rhesusmacaquemodelofasianlineagezikavirusinfection AT danedgellerup rhesusmacaquemodelofasianlineagezikavirusinfection AT louisehmoncla rhesusmacaquemodelofasianlineagezikavirusinfection AT jenniferpost rhesusmacaquemodelofasianlineagezikavirusinfection AT nancyschultzdarken rhesusmacaquemodelofasianlineagezikavirusinfection AT michelelschotzko rhesusmacaquemodelofasianlineagezikavirusinfection AT jennifermhayes rhesusmacaquemodelofasianlineagezikavirusinfection AT joshaeudailey rhesusmacaquemodelofasianlineagezikavirusinfection AT manthonymoody rhesusmacaquemodelofasianlineagezikavirusinfection AT sallierpermar rhesusmacaquemodelofasianlineagezikavirusinfection AT shelbyloconnor rhesusmacaquemodelofasianlineagezikavirusinfection AT evagrakasz rhesusmacaquemodelofasianlineagezikavirusinfection AT heatherasimmons rhesusmacaquemodelofasianlineagezikavirusinfection AT saveriocapuano rhesusmacaquemodelofasianlineagezikavirusinfection AT thaddeusggolos rhesusmacaquemodelofasianlineagezikavirusinfection AT jorgeeosorio rhesusmacaquemodelofasianlineagezikavirusinfection AT thomascfriedrich rhesusmacaquemodelofasianlineagezikavirusinfection AT davidhoconnor rhesusmacaquemodelofasianlineagezikavirusinfection |