Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan
In this presented case, a 77-year-old woman with an implanted prosthesis and ongoing knee pain underwent a bone scan using <sup>99m</sup>Tc-hydroxydiphosphonate (HDP) in suspicion for bone infection. An incidental finding from this scan revealed diffuse cardiac uptake, necessitating furt...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/21/3342 |
| _version_ | 1797632045912948736 |
|---|---|
| author | Yeongjoo Lee Jaehyuk Jang Sae Jung Na |
| author_facet | Yeongjoo Lee Jaehyuk Jang Sae Jung Na |
| author_sort | Yeongjoo Lee |
| collection | DOAJ |
| description | In this presented case, a 77-year-old woman with an implanted prosthesis and ongoing knee pain underwent a bone scan using <sup>99m</sup>Tc-hydroxydiphosphonate (HDP) in suspicion for bone infection. An incidental finding from this scan revealed diffuse cardiac uptake, necessitating further diagnostic procedures to exclude the possibility of cardiac amyloidosis. In the subsequent <sup>99m</sup>Tc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and SPECT images, no perceptible cardiac uptake was observed at all. Upon retrospective review of the patient’s medical records, she received 1000 mg of ferric carboxymaltose for iron-deficient anemia the day before the <sup>99m</sup>Tc-HDP bone scan. Therefore, it was assumed that the diffuse and temporary cardiac activity was due to the transient iron overload. We present and share these bone scan images in order to avoid possible future misinterpretation of cardiac amyloidosis. |
| first_indexed | 2024-03-11T11:31:22Z |
| format | Article |
| id | doaj.art-1d50e3b11dad4e19927e85a24dd7fc2d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T11:31:22Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1d50e3b11dad4e19927e85a24dd7fc2d2023-11-10T15:01:02ZengMDPI AGDiagnostics2075-44182023-10-011321334210.3390/diagnostics13213342Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone ScanYeongjoo Lee0Jaehyuk Jang1Sae Jung Na2Department of Radiology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDivision of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Radiology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaIn this presented case, a 77-year-old woman with an implanted prosthesis and ongoing knee pain underwent a bone scan using <sup>99m</sup>Tc-hydroxydiphosphonate (HDP) in suspicion for bone infection. An incidental finding from this scan revealed diffuse cardiac uptake, necessitating further diagnostic procedures to exclude the possibility of cardiac amyloidosis. In the subsequent <sup>99m</sup>Tc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and SPECT images, no perceptible cardiac uptake was observed at all. Upon retrospective review of the patient’s medical records, she received 1000 mg of ferric carboxymaltose for iron-deficient anemia the day before the <sup>99m</sup>Tc-HDP bone scan. Therefore, it was assumed that the diffuse and temporary cardiac activity was due to the transient iron overload. We present and share these bone scan images in order to avoid possible future misinterpretation of cardiac amyloidosis.https://www.mdpi.com/2075-4418/13/21/3342bone scan<sup>99m</sup>Tc-HDPcardiac amyloidosisiron overload |
| spellingShingle | Yeongjoo Lee Jaehyuk Jang Sae Jung Na Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan Diagnostics bone scan <sup>99m</sup>Tc-HDP cardiac amyloidosis iron overload |
| title | Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan |
| title_full | Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan |
| title_fullStr | Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan |
| title_full_unstemmed | Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan |
| title_short | Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan |
| title_sort | diffuse cardiac uptake misdiagnosed as cardiac amyloidosis in bone scan |
| topic | bone scan <sup>99m</sup>Tc-HDP cardiac amyloidosis iron overload |
| url | https://www.mdpi.com/2075-4418/13/21/3342 |
| work_keys_str_mv | AT yeongjoolee diffusecardiacuptakemisdiagnosedascardiacamyloidosisinbonescan AT jaehyukjang diffusecardiacuptakemisdiagnosedascardiacamyloidosisinbonescan AT saejungna diffusecardiacuptakemisdiagnosedascardiacamyloidosisinbonescan |