MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities

MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities

Stress-associated premature senescence (SAPS) is involved in retinal microvascular injury and diabetic retinopathy. We have investigated the role and mode of action of miR-34a in retinal endothelial cells senescence in response to glucidic stress. Human retinal microvascular endothelial cells (HuREC...

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Bibliographic Details
Main Authors: Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Marie Warren, Folami L. Powell, Raghavan Raju, Diana Gutsaeva, Sandeep Khurana, Pamela M. Martin, Manuela Bartoli
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Antioxidants
Subjects:
diabetic retinopathy
mitochondrial dysfunction
miR-34a
vascular senescence
Online Access:https://www.mdpi.com/2076-3921/8/9/328

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