Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance
Acquired drug resistance represents a major clinical problem and one of the biggest limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using standard chemotherapeutic agents, together with bioactive natural compounds derived from diet or plants, may be one of the mos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1948 |
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| author | Laura Ioana Gavrilas Daniel Cruceriu Andrei Mocan Felicia Loghin Doina Miere Ovidiu Balacescu |
| author_facet | Laura Ioana Gavrilas Daniel Cruceriu Andrei Mocan Felicia Loghin Doina Miere Ovidiu Balacescu |
| author_sort | Laura Ioana Gavrilas |
| collection | DOAJ |
| description | Acquired drug resistance represents a major clinical problem and one of the biggest limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using standard chemotherapeutic agents, together with bioactive natural compounds derived from diet or plants, may be one of the most valuable strategies to overcome drug resistance and re-sensitize chemoresistant cells. In this review, we highlight the effect of combined regimens based on conventional chemotherapeutics in conjunction with well-tolerated plant-derived bioactive compounds, mainly curcumin, resveratrol, and EGCG, with emphasis on the molecular mechanisms associated with the acquired drug resistance. |
| first_indexed | 2024-03-09T10:00:10Z |
| format | Article |
| id | doaj.art-1d52a3e1339a43fa9901bbdafc68ffec |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:00:10Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1d52a3e1339a43fa9901bbdafc68ffec2023-12-01T23:28:07ZengMDPI AGBiomedicines2227-90592022-08-01108194810.3390/biomedicines10081948Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-ResistanceLaura Ioana Gavrilas0Daniel Cruceriu1Andrei Mocan2Felicia Loghin3Doina Miere4Ovidiu Balacescu5Department of Bromatology, Hygiene, Nutrition, “Iuliu Hatieganu” University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaDepartment of Functional Genomics, Proteomics and Experimental Pathology, “Prof. Dr. Ion Chiricuta” Oncology Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, “Iuliu Hatieganu” University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaDepartment of Toxicology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, RomaniaDepartment of Bromatology, Hygiene, Nutrition, “Iuliu Hatieganu” University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaDepartment of Functional Genomics, Proteomics and Experimental Pathology, “Prof. Dr. Ion Chiricuta” Oncology Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, RomaniaAcquired drug resistance represents a major clinical problem and one of the biggest limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using standard chemotherapeutic agents, together with bioactive natural compounds derived from diet or plants, may be one of the most valuable strategies to overcome drug resistance and re-sensitize chemoresistant cells. In this review, we highlight the effect of combined regimens based on conventional chemotherapeutics in conjunction with well-tolerated plant-derived bioactive compounds, mainly curcumin, resveratrol, and EGCG, with emphasis on the molecular mechanisms associated with the acquired drug resistance.https://www.mdpi.com/2227-9059/10/8/1948combination therapychemotherapy resistancecolorectal cancerdrug resistancecurcuminresveratrol |
| spellingShingle | Laura Ioana Gavrilas Daniel Cruceriu Andrei Mocan Felicia Loghin Doina Miere Ovidiu Balacescu Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance Biomedicines combination therapy chemotherapy resistance colorectal cancer drug resistance curcumin resveratrol |
| title | Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance |
| title_full | Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance |
| title_fullStr | Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance |
| title_full_unstemmed | Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance |
| title_short | Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance |
| title_sort | plant derived bioactive compounds in colorectal cancer insights from combined regimens with conventional chemotherapy to overcome drug resistance |
| topic | combination therapy chemotherapy resistance colorectal cancer drug resistance curcumin resveratrol |
| url | https://www.mdpi.com/2227-9059/10/8/1948 |
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