D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine
Fused filament fabrication (FFF) is a process used to manufacture oral forms adapted to the needs of patients. Polyethylene oxide (PEO) filaments were produced by hot melt extrusion (HME) to obtain a filament suitable for the production of amiodarone hydrochloride oral forms by FFF 3D printing. In o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/10/3000 |
| _version_ | 1797533593926369280 |
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| author | Stéphane Roulon Ian Soulairol Maxime Cazes Léna Lemierre Nicolas Payre Laurent Delbreilh Jean Alié |
| author_facet | Stéphane Roulon Ian Soulairol Maxime Cazes Léna Lemierre Nicolas Payre Laurent Delbreilh Jean Alié |
| author_sort | Stéphane Roulon |
| collection | DOAJ |
| description | Fused filament fabrication (FFF) is a process used to manufacture oral forms adapted to the needs of patients. Polyethylene oxide (PEO) filaments were produced by hot melt extrusion (HME) to obtain a filament suitable for the production of amiodarone hydrochloride oral forms by FFF 3D printing. In order to produce personalized oral forms adapted to the patient characteristics, filaments used by FFF must be controlled in terms of mass homogeneity along filament. This work highlights the relation between filament mass homogeneity and its diameter. This is why the impact of filler excipients physical properties was studied. It has been showed that the particle’s size distribution of the filler can modify the filament diameter variability which has had an impact on the mass of oral forms produced by FFF. Through this work it was shown that D-Sorbitol from Carlo Erba allows to obtain a diameter variability of less than 2% due to its unique particle’s size distribution. Using the filament produced by HME and an innovating calibration method based on the filament length, it has been possible to carry out three dosages of 125 mg, 750 mg and 1000 mg by 3D printing with acceptable mass uniformity. |
| first_indexed | 2024-03-10T11:17:48Z |
| format | Article |
| id | doaj.art-1d541bc9f1b74d37abc475efcbab9cf9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:17:48Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1d541bc9f1b74d37abc475efcbab9cf92023-11-21T20:16:53ZengMDPI AGMolecules1420-30492021-05-012610300010.3390/molecules26103000D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized MedicineStéphane Roulon0Ian Soulairol1Maxime Cazes2Léna Lemierre3Nicolas Payre4Laurent Delbreilh5Jean Alié6Group of Materials Physics, UNIROUEN Normandie, INSA Rouen, CNRS, Normandie University, Av. Université, 76801 St Etienne du Rouvray, FranceDepartment of Pharmacy, Nîmes University Hospital, 30900 Nimes, FranceSolid State Characterization and 3D Printing Laboratory, SMO-A Department, Sanofi R&D, 371 rue du Pr. Joseph Blayac, 34080 Montpellier, FranceSolid State Characterization and 3D Printing Laboratory, SMO-A Department, Sanofi R&D, 371 rue du Pr. Joseph Blayac, 34080 Montpellier, FranceSolid State Characterization and 3D Printing Laboratory, SMO-A Department, Sanofi R&D, 371 rue du Pr. Joseph Blayac, 34080 Montpellier, FranceGroup of Materials Physics, UNIROUEN Normandie, INSA Rouen, CNRS, Normandie University, Av. Université, 76801 St Etienne du Rouvray, FranceSolid State Characterization and 3D Printing Laboratory, SMO-A Department, Sanofi R&D, 371 rue du Pr. Joseph Blayac, 34080 Montpellier, FranceFused filament fabrication (FFF) is a process used to manufacture oral forms adapted to the needs of patients. Polyethylene oxide (PEO) filaments were produced by hot melt extrusion (HME) to obtain a filament suitable for the production of amiodarone hydrochloride oral forms by FFF 3D printing. In order to produce personalized oral forms adapted to the patient characteristics, filaments used by FFF must be controlled in terms of mass homogeneity along filament. This work highlights the relation between filament mass homogeneity and its diameter. This is why the impact of filler excipients physical properties was studied. It has been showed that the particle’s size distribution of the filler can modify the filament diameter variability which has had an impact on the mass of oral forms produced by FFF. Through this work it was shown that D-Sorbitol from Carlo Erba allows to obtain a diameter variability of less than 2% due to its unique particle’s size distribution. Using the filament produced by HME and an innovating calibration method based on the filament length, it has been possible to carry out three dosages of 125 mg, 750 mg and 1000 mg by 3D printing with acceptable mass uniformity.https://www.mdpi.com/1420-3049/26/10/30003D printingfused filament fabricationhot melt extrusionoral dosage formsfilamentpersonalized medicine |
| spellingShingle | Stéphane Roulon Ian Soulairol Maxime Cazes Léna Lemierre Nicolas Payre Laurent Delbreilh Jean Alié D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine Molecules 3D printing fused filament fabrication hot melt extrusion oral dosage forms filament personalized medicine |
| title | D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine |
| title_full | D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine |
| title_fullStr | D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine |
| title_full_unstemmed | D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine |
| title_short | D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine |
| title_sort | d sorbitol physical properties effects on filaments used by 3d printing process for personalized medicine |
| topic | 3D printing fused filament fabrication hot melt extrusion oral dosage forms filament personalized medicine |
| url | https://www.mdpi.com/1420-3049/26/10/3000 |
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