Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents
Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/11/2296 |
| _version_ | 1797492142257471488 |
|---|---|
| author | Christopher Morrissey Marie-Josèphe Amiot Aurelie Goncalves Cecile Raverdy Delphine Masson Catherine Tardivel Sandrine Gayrard Myriam Carrère Jean-Francois Landrier Agnes Vinet Antonia Perez-Martin |
| author_facet | Christopher Morrissey Marie-Josèphe Amiot Aurelie Goncalves Cecile Raverdy Delphine Masson Catherine Tardivel Sandrine Gayrard Myriam Carrère Jean-Francois Landrier Agnes Vinet Antonia Perez-Martin |
| author_sort | Christopher Morrissey |
| collection | DOAJ |
| description | Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned to receive either a 12-week lifestyle program with VD supplementation (<i>n</i> = 13), a lifestyle program without VD supplementation (<i>n</i> = 13) or a control group composed of normal-weight adolescents (<i>n</i> = 18). Serum total and free 25-hydroxyvitamin D (25(OH)D), IMT and carotid compliance were measured before and after the trial. Insufficiency in 25(OH)D concentration was found in 73% of obese participants compared to 22% among controls. Obese adolescents had lower free 25(OH)D and displayed higher IMT but lower carotid compliance than controls. Free 25(OH)D and IMT were negatively correlated in adolescents displaying VD insufficiency at baseline. After three months, total and free 25(OH)D increased in both groups. The changes of IMT and carotid compliance were similar between groups. The changes in IMT were correlated with the changes in total 25(OH)D in obese adolescents with VD insufficiency at baseline (<i>r</i> = −0.59, <i>p</i> = 0.03). While the lifestyle program with VD supplementation did not affect carotid compliance, IMT reduction was improved in obese adolescents. |
| first_indexed | 2024-03-10T00:59:21Z |
| format | Article |
| id | doaj.art-1d568b26808142a5bf75b6abf5acd4a2 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:59:21Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1d568b26808142a5bf75b6abf5acd4a22023-11-23T14:36:48ZengMDPI AGNutrients2072-66432022-05-011411229610.3390/nu14112296Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese AdolescentsChristopher Morrissey0Marie-Josèphe Amiot1Aurelie Goncalves2Cecile Raverdy3Delphine Masson4Catherine Tardivel5Sandrine Gayrard6Myriam Carrère7Jean-Francois Landrier8Agnes Vinet9Antonia Perez-Martin10LAPEC UPR4278—Laboratoire de Pharm-Ecologie Cardiovasculaire, Avignon University, 84029 Avignon, FranceMOISA—Montpellier Interdisciplinary Center on Sustainable Agri-Food Systems, CIRAD—Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut Agro-SupAgro, University Montpellier, INRAE—National Research Institute for Agriculture, Food and the Environment, CIHEAM-IAMM—International Centre for Advanced Mediterranean Agronomic Studies-Mediterranean Agronomic Institute of Montpellier, 34090 Montpellier, FranceAPSY-V—Laboratoire APSY-v, University Nimes, 30021 Nîmes, FranceSSR—Centre de Soins de Suite et de Réadaptation, Institut Saint Pierre, 34250 Palavas-les-Flots, FranceSSR—Centre de Soins de Suite et de Réadaptation, Institut Saint Pierre, 34250 Palavas-les-Flots, FranceUMR C2VN—Center for CardioVascular and Nutrition Research, Aix Marseille University, INSERM—National Institute of Health and Medical Research, INRAE—National Research Institute for Agriculture, Food and the Environment, 13385 Marseille, FranceLAPEC UPR4278—Laboratoire de Pharm-Ecologie Cardiovasculaire, Avignon University, 84029 Avignon, FranceMOISA—Montpellier Interdisciplinary Center on Sustainable Agri-Food Systems, CIRAD—Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut Agro-SupAgro, University Montpellier, INRAE—National Research Institute for Agriculture, Food and the Environment, CIHEAM-IAMM—International Centre for Advanced Mediterranean Agronomic Studies-Mediterranean Agronomic Institute of Montpellier, 34090 Montpellier, FranceUMR C2VN—Center for CardioVascular and Nutrition Research, Aix Marseille University, INSERM—National Institute of Health and Medical Research, INRAE—National Research Institute for Agriculture, Food and the Environment, 13385 Marseille, FranceLAPEC UPR4278—Laboratoire de Pharm-Ecologie Cardiovasculaire, Avignon University, 84029 Avignon, FranceVascular Medicine Laboratory, Nimes University Hospital, 30900 Nimes, FranceObesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned to receive either a 12-week lifestyle program with VD supplementation (<i>n</i> = 13), a lifestyle program without VD supplementation (<i>n</i> = 13) or a control group composed of normal-weight adolescents (<i>n</i> = 18). Serum total and free 25-hydroxyvitamin D (25(OH)D), IMT and carotid compliance were measured before and after the trial. Insufficiency in 25(OH)D concentration was found in 73% of obese participants compared to 22% among controls. Obese adolescents had lower free 25(OH)D and displayed higher IMT but lower carotid compliance than controls. Free 25(OH)D and IMT were negatively correlated in adolescents displaying VD insufficiency at baseline. After three months, total and free 25(OH)D increased in both groups. The changes of IMT and carotid compliance were similar between groups. The changes in IMT were correlated with the changes in total 25(OH)D in obese adolescents with VD insufficiency at baseline (<i>r</i> = −0.59, <i>p</i> = 0.03). While the lifestyle program with VD supplementation did not affect carotid compliance, IMT reduction was improved in obese adolescents.https://www.mdpi.com/2072-6643/14/11/2296childhood obesityvitamin Darterial stiffnessintima-media thickness |
| spellingShingle | Christopher Morrissey Marie-Josèphe Amiot Aurelie Goncalves Cecile Raverdy Delphine Masson Catherine Tardivel Sandrine Gayrard Myriam Carrère Jean-Francois Landrier Agnes Vinet Antonia Perez-Martin Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents Nutrients childhood obesity vitamin D arterial stiffness intima-media thickness |
| title | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
| title_full | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
| title_fullStr | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
| title_full_unstemmed | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
| title_short | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
| title_sort | vitamin d supplementation on carotid remodeling and stiffness in obese adolescents |
| topic | childhood obesity vitamin D arterial stiffness intima-media thickness |
| url | https://www.mdpi.com/2072-6643/14/11/2296 |
| work_keys_str_mv | AT christophermorrissey vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT mariejosepheamiot vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT aureliegoncalves vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT cecileraverdy vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT delphinemasson vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT catherinetardivel vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT sandrinegayrard vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT myriamcarrere vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT jeanfrancoislandrier vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT agnesvinet vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents AT antoniaperezmartin vitamindsupplementationoncarotidremodelingandstiffnessinobeseadolescents |