Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis
Abstract Background Although it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations differ among breast cancer subtypes defined by the tumor protein express...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Breast Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13058-017-0931-5 |
| _version_ | 1819276662170189824 |
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| author | Huiyan Ma Giske Ursin Xinxin Xu Eunjung Lee Kayo Togawa Kathleen E. Malone Polly A. Marchbanks Jill A. McDonald Michael S. Simon Suzanne G. Folger Yani Lu Jane Sullivan-Halley Dennis M. Deapen Michael F. Press Leslie Bernstein |
| author_facet | Huiyan Ma Giske Ursin Xinxin Xu Eunjung Lee Kayo Togawa Kathleen E. Malone Polly A. Marchbanks Jill A. McDonald Michael S. Simon Suzanne G. Folger Yani Lu Jane Sullivan-Halley Dennis M. Deapen Michael F. Press Leslie Bernstein |
| author_sort | Huiyan Ma |
| collection | DOAJ |
| description | Abstract Background Although it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations differ among breast cancer subtypes defined by the tumor protein expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Methods We evaluated the associations of body mass index (BMI) at age 18 years and recent BMI in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes, in 6320 women (3934 case-patient participants, 2386 control participants) aged 35–64 years, who participated in one of three population-based case-control studies. We estimated multivariable-adjusted odd ratios (ORs) and corresponding 95% confidence intervals (CIs) using polychotomous unconditional logistic regression methods for case-control comparisons in premenopausal women and postmenopausal women. Results BMI at age 18 years was inversely associated with risk of breast cancer, particularly among premenopausal women (≥ 25 vs. < 20 kg/m2, OR = 0.72, 95% CI = 0.53–0.96; per 5 kg/m2 increase, OR = 0.83, 95% CI = 0.73–0.95). This inverse association did not differ across ER/PR/HER2-defined subtypes or by race (white women, African-American women). Recent BMI was not associated with risk of premenopausal breast cancer after adjustment for BMI at age 18 years; nevertheless, the analysis for the joint effects of BMI at age 18 years and recent BMI showed that premenopausal women in the highest categories of the two BMI measures (≥ 25 kg/m2 at age 18 years and ≥ 30 kg/m2 for recent BMI) had 46% lower risk of breast cancer than premenopausal women in the lowest categories of the two BMI measures (< 20 kg/m2 at age 18 years and < 25 kg/m2 for recent BMI; OR = 0.54, 95% CI = 0.38–0.78). Neither measure of BMI was statistically significantly associated with risk of postmenopausal breast cancer. Conclusion Our findings indicate that high BMI near the end of adolescence decreases risk of all ER/PR/HER2-defined subtypes of premenopausal breast cancer and also suggest that this benefit could be maximized among premenopausal women who consistently have high BMI during their premenopausal years. |
| first_indexed | 2024-12-23T23:43:47Z |
| format | Article |
| id | doaj.art-1d56dcfe3e3140fe8bac21b8e996c19b |
| institution | Directory Open Access Journal |
| issn | 1465-542X |
| language | English |
| last_indexed | 2024-12-23T23:43:47Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj.art-1d56dcfe3e3140fe8bac21b8e996c19b2022-12-21T17:25:33ZengBMCBreast Cancer Research1465-542X2018-01-0120111410.1186/s13058-017-0931-5Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysisHuiyan Ma0Giske Ursin1Xinxin Xu2Eunjung Lee3Kayo Togawa4Kathleen E. Malone5Polly A. Marchbanks6Jill A. McDonald7Michael S. Simon8Suzanne G. Folger9Yani Lu10Jane Sullivan-Halley11Dennis M. Deapen12Michael F. Press13Leslie Bernstein14Department of Population Sciences, Beckman Research Institute, City of HopeCancer Registry of NorwayDepartment of Population Sciences, Beckman Research Institute, City of HopeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern CaliforniaDepartment of Population Sciences, Beckman Research Institute, City of HopeDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterDivision of Reproductive Health, Centers for Disease Control and PreventionCollege of Health and Social Services, New Mexico State UniversityKarmanos Cancer Institute, Department of Oncology, Wayne State UniversityDivision of Reproductive Health, Centers for Disease Control and PreventionDepartment of Population Sciences, Beckman Research Institute, City of HopeDepartment of Population Sciences, Beckman Research Institute, City of HopeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern CaliforniaPathology, Keck School of Medicine, University of Southern CaliforniaDepartment of Population Sciences, Beckman Research Institute, City of HopeAbstract Background Although it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations differ among breast cancer subtypes defined by the tumor protein expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Methods We evaluated the associations of body mass index (BMI) at age 18 years and recent BMI in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes, in 6320 women (3934 case-patient participants, 2386 control participants) aged 35–64 years, who participated in one of three population-based case-control studies. We estimated multivariable-adjusted odd ratios (ORs) and corresponding 95% confidence intervals (CIs) using polychotomous unconditional logistic regression methods for case-control comparisons in premenopausal women and postmenopausal women. Results BMI at age 18 years was inversely associated with risk of breast cancer, particularly among premenopausal women (≥ 25 vs. < 20 kg/m2, OR = 0.72, 95% CI = 0.53–0.96; per 5 kg/m2 increase, OR = 0.83, 95% CI = 0.73–0.95). This inverse association did not differ across ER/PR/HER2-defined subtypes or by race (white women, African-American women). Recent BMI was not associated with risk of premenopausal breast cancer after adjustment for BMI at age 18 years; nevertheless, the analysis for the joint effects of BMI at age 18 years and recent BMI showed that premenopausal women in the highest categories of the two BMI measures (≥ 25 kg/m2 at age 18 years and ≥ 30 kg/m2 for recent BMI) had 46% lower risk of breast cancer than premenopausal women in the lowest categories of the two BMI measures (< 20 kg/m2 at age 18 years and < 25 kg/m2 for recent BMI; OR = 0.54, 95% CI = 0.38–0.78). Neither measure of BMI was statistically significantly associated with risk of postmenopausal breast cancer. Conclusion Our findings indicate that high BMI near the end of adolescence decreases risk of all ER/PR/HER2-defined subtypes of premenopausal breast cancer and also suggest that this benefit could be maximized among premenopausal women who consistently have high BMI during their premenopausal years.http://link.springer.com/article/10.1186/s13058-017-0931-5Body sizeBody mass indexBreast cancerTriple negativeLuminal-likeAfrican-American women |
| spellingShingle | Huiyan Ma Giske Ursin Xinxin Xu Eunjung Lee Kayo Togawa Kathleen E. Malone Polly A. Marchbanks Jill A. McDonald Michael S. Simon Suzanne G. Folger Yani Lu Jane Sullivan-Halley Dennis M. Deapen Michael F. Press Leslie Bernstein Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis Breast Cancer Research Body size Body mass index Breast cancer Triple negative Luminal-like African-American women |
| title | Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis |
| title_full | Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis |
| title_fullStr | Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis |
| title_full_unstemmed | Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis |
| title_short | Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis |
| title_sort | body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and er pr her2 defined subtypes in white women and african american women a pooled analysis |
| topic | Body size Body mass index Breast cancer Triple negative Luminal-like African-American women |
| url | http://link.springer.com/article/10.1186/s13058-017-0931-5 |
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