Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study
BackgroundSystemic immune-inflammation index (SII) is a novel inflammatory marker, and inflammation has been reported to be related with renal damage. We aimed to investigate the possible relationship between SII and albuminuria.MethodsThe present cross-sectional study was conducted among adults wit...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.863640/full |
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| author | Zheng Qin Zheng Qin Zheng Qin Hancong Li Liya Wang Liya Wang Liya Wang Jiwen Geng Jiwen Geng Jiwen Geng Qinbo Yang Qinbo Yang Qinbo Yang Baihai Su Baihai Su Baihai Su Ruoxi Liao Ruoxi Liao Ruoxi Liao |
| author_facet | Zheng Qin Zheng Qin Zheng Qin Hancong Li Liya Wang Liya Wang Liya Wang Jiwen Geng Jiwen Geng Jiwen Geng Qinbo Yang Qinbo Yang Qinbo Yang Baihai Su Baihai Su Baihai Su Ruoxi Liao Ruoxi Liao Ruoxi Liao |
| author_sort | Zheng Qin |
| collection | DOAJ |
| description | BackgroundSystemic immune-inflammation index (SII) is a novel inflammatory marker, and inflammation has been reported to be related with renal damage. We aimed to investigate the possible relationship between SII and albuminuria.MethodsThe present cross-sectional study was conducted among adults with complete data about SII and urinary albumin-to-creatinine ratio (ACR) in 2005–2018 National Health and Nutrition Examination Survey (NHANES). SII was calculated as the platelet count × neutrophil count/lymphocyte count. Albuminuria was defined as ACR >30mg/g. Weighted multivariable regression analysis and subgroup analysis were conducted to explore the independent relationship between SII and albuminuria.ResultsA total of 36,463 individuals were included in our analysis; 9.56% participants were categorized as having albuminuria overall and increased with the higher SII tertiles (tertile 1, 7.83%; tertile 2, 8.49%; tertile 3, 12.13%; p for trend <0.0001). Multivariable logistic regression showed that a higher SII level was associated with increased likelihood of albuminuria independently (OR = 1.31; 95% CI, 1.17–1.48, p<0.0001) after full adjustment. Subgroup analysis and interaction test showed that there was no significant dependence of gender, age, body mass index, hypertension, diabetes, non‐alcoholic fatty liver disease, and estimated glomerular filtration rate (eGFR) on this positive association (all p for interaction >0.05).ConclusionsSII was positively associated with increased urinary albumin excretion in US adults. Further large-scale prospective studies are still needed to analyze the role of SII in albuminuria. |
| first_indexed | 2024-12-13T09:32:22Z |
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| id | doaj.art-1d590e5f12ed4213adc827b14e88f6dc |
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| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T09:32:22Z |
| publishDate | 2022-03-01 |
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| spelling | doaj.art-1d590e5f12ed4213adc827b14e88f6dc2022-12-21T23:52:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.863640863640Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based StudyZheng Qin0Zheng Qin1Zheng Qin2Hancong Li3Liya Wang4Liya Wang5Liya Wang6Jiwen Geng7Jiwen Geng8Jiwen Geng9Qinbo Yang10Qinbo Yang11Qinbo Yang12Baihai Su13Baihai Su14Baihai Su15Ruoxi Liao16Ruoxi Liao17Ruoxi Liao18Department of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaMed+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu, ChinaMed-X Center for Materials, Sichuan University, Chengdu, ChinaWest China School of Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaMed+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu, ChinaMed-X Center for Materials, Sichuan University, Chengdu, ChinaDepartment of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaMed+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu, ChinaMed-X Center for Materials, Sichuan University, Chengdu, ChinaDepartment of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaMed+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu, ChinaMed-X Center for Materials, Sichuan University, Chengdu, ChinaDepartment of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaMed+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu, ChinaMed-X Center for Materials, Sichuan University, Chengdu, ChinaDepartment of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaMed+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu, ChinaMed-X Center for Materials, Sichuan University, Chengdu, ChinaBackgroundSystemic immune-inflammation index (SII) is a novel inflammatory marker, and inflammation has been reported to be related with renal damage. We aimed to investigate the possible relationship between SII and albuminuria.MethodsThe present cross-sectional study was conducted among adults with complete data about SII and urinary albumin-to-creatinine ratio (ACR) in 2005–2018 National Health and Nutrition Examination Survey (NHANES). SII was calculated as the platelet count × neutrophil count/lymphocyte count. Albuminuria was defined as ACR >30mg/g. Weighted multivariable regression analysis and subgroup analysis were conducted to explore the independent relationship between SII and albuminuria.ResultsA total of 36,463 individuals were included in our analysis; 9.56% participants were categorized as having albuminuria overall and increased with the higher SII tertiles (tertile 1, 7.83%; tertile 2, 8.49%; tertile 3, 12.13%; p for trend <0.0001). Multivariable logistic regression showed that a higher SII level was associated with increased likelihood of albuminuria independently (OR = 1.31; 95% CI, 1.17–1.48, p<0.0001) after full adjustment. Subgroup analysis and interaction test showed that there was no significant dependence of gender, age, body mass index, hypertension, diabetes, non‐alcoholic fatty liver disease, and estimated glomerular filtration rate (eGFR) on this positive association (all p for interaction >0.05).ConclusionsSII was positively associated with increased urinary albumin excretion in US adults. Further large-scale prospective studies are still needed to analyze the role of SII in albuminuria.https://www.frontiersin.org/articles/10.3389/fimmu.2022.863640/fullsystemic immune-inflammation indexalbuminuriapopulation-based studyNHANEScross-sectional study |
| spellingShingle | Zheng Qin Zheng Qin Zheng Qin Hancong Li Liya Wang Liya Wang Liya Wang Jiwen Geng Jiwen Geng Jiwen Geng Qinbo Yang Qinbo Yang Qinbo Yang Baihai Su Baihai Su Baihai Su Ruoxi Liao Ruoxi Liao Ruoxi Liao Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study Frontiers in Immunology systemic immune-inflammation index albuminuria population-based study NHANES cross-sectional study |
| title | Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study |
| title_full | Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study |
| title_fullStr | Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study |
| title_full_unstemmed | Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study |
| title_short | Systemic Immune-Inflammation Index Is Associated With Increased Urinary Albumin Excretion: A Population-Based Study |
| title_sort | systemic immune inflammation index is associated with increased urinary albumin excretion a population based study |
| topic | systemic immune-inflammation index albuminuria population-based study NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.863640/full |
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