Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and Research
Background Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship. Objectives Samples of FDOJ were analyzed to assess expression of cytokines which...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2014-01-01
|
| Series: | Breast Cancer: Basic and Clinical Research |
| Online Access: | https://doi.org/10.4137/BCBCR.S15119 |
| _version_ | 1818097313301659648 |
|---|---|
| author | Johann Lechner Volker Von Baehr |
| author_facet | Johann Lechner Volker Von Baehr |
| author_sort | Johann Lechner |
| collection | DOAJ |
| description | Background Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship. Objectives Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa). Material and Methods Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers. Results RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators. Discussion This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa. Conclusion We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production. |
| first_indexed | 2024-12-10T23:18:32Z |
| format | Article |
| id | doaj.art-1d5934b4ab4247f8bf88c89e557b5f62 |
| institution | Directory Open Access Journal |
| issn | 1178-2234 |
| language | English |
| last_indexed | 2024-12-10T23:18:32Z |
| publishDate | 2014-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Breast Cancer: Basic and Clinical Research |
| spelling | doaj.art-1d5934b4ab4247f8bf88c89e557b5f622022-12-22T01:29:46ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342014-01-01810.4137/BCBCR.S15119Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and ResearchJohann Lechner0Volker Von Baehr1Head of Clinic for Integrative Dentistry, Munich, Germany.Medical Head of Compartment of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany.Background Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship. Objectives Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa). Material and Methods Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers. Results RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators. Discussion This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa. Conclusion We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.https://doi.org/10.4137/BCBCR.S15119 |
| spellingShingle | Johann Lechner Volker Von Baehr Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and Research Breast Cancer: Basic and Clinical Research |
| title | Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and Research |
| title_full | Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and Research |
| title_fullStr | Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and Research |
| title_full_unstemmed | Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and Research |
| title_short | Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and Research |
| title_sort | hyperactivated signaling pathways of chemokine rantes ccl5 in osteopathies of jawbone in breast cancer patients case report and research |
| url | https://doi.org/10.4137/BCBCR.S15119 |
| work_keys_str_mv | AT johannlechner hyperactivatedsignalingpathwaysofchemokinerantesccl5inosteopathiesofjawboneinbreastcancerpatientscasereportandresearch AT volkervonbaehr hyperactivatedsignalingpathwaysofchemokinerantesccl5inosteopathiesofjawboneinbreastcancerpatientscasereportandresearch |