A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species
A new 1,4-diazepine, callysponine (1), was isolated from a South China Sea Callyspongia sp. marine sponge, together with four known proline-based diketopiperazines: cyclo-(S-Pro-R-Leu) (2), cyclo-(S-Pro-R-Val) (3), cyclo-(S-Pro-R-Ala) (4), andcyclo-(S-Pro-R-Tyr) (5). The new structure was determined...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/2/871/ |
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| author | Shi-Hai Xu Xianwen Yang Kyung Jin Lee Tunhai Xu Xue-Feng Zhou Wei Ma Jun-De Dong Ri-Ming Huang Yonghong Liu |
| author_facet | Shi-Hai Xu Xianwen Yang Kyung Jin Lee Tunhai Xu Xue-Feng Zhou Wei Ma Jun-De Dong Ri-Ming Huang Yonghong Liu |
| author_sort | Shi-Hai Xu |
| collection | DOAJ |
| description | A new 1,4-diazepine, callysponine (1), was isolated from a South China Sea Callyspongia sp. marine sponge, together with four known proline-based diketopiperazines: cyclo-(S-Pro-R-Leu) (2), cyclo-(S-Pro-R-Val) (3), cyclo-(S-Pro-R-Ala) (4), andcyclo-(S-Pro-R-Tyr) (5). The new structure was determined on the basis of NMR and MS analysis, and the absolute stereochemistry was defined by NOESY spectroscopy and optical rotation. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. Callysponine (1) did not inhibit the growth of HepG2 (hepatoma carcinoma cell), A549 (lung carcinoma cell), and HeLa (cervical cancer cell) cell lines. |
| first_indexed | 2024-12-10T17:49:07Z |
| format | Article |
| id | doaj.art-1d5be72e9dbe4853be310e83e71b888d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T17:49:07Z |
| publishDate | 2010-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1d5be72e9dbe4853be310e83e71b888d2022-12-22T01:39:07ZengMDPI AGMolecules1420-30492010-02-0115287187710.3390/molecules15020871A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia SpeciesShi-Hai XuXianwen YangKyung Jin LeeTunhai XuXue-Feng ZhouWei MaJun-De DongRi-Ming HuangYonghong LiuA new 1,4-diazepine, callysponine (1), was isolated from a South China Sea Callyspongia sp. marine sponge, together with four known proline-based diketopiperazines: cyclo-(S-Pro-R-Leu) (2), cyclo-(S-Pro-R-Val) (3), cyclo-(S-Pro-R-Ala) (4), andcyclo-(S-Pro-R-Tyr) (5). The new structure was determined on the basis of NMR and MS analysis, and the absolute stereochemistry was defined by NOESY spectroscopy and optical rotation. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. Callysponine (1) did not inhibit the growth of HepG2 (hepatoma carcinoma cell), A549 (lung carcinoma cell), and HeLa (cervical cancer cell) cell lines.http://www.mdpi.com/1420-3049/15/2/871/marine spongeCallyspongia sp.diazepinecallysponine |
| spellingShingle | Shi-Hai Xu Xianwen Yang Kyung Jin Lee Tunhai Xu Xue-Feng Zhou Wei Ma Jun-De Dong Ri-Ming Huang Yonghong Liu A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species Molecules marine sponge Callyspongia sp. diazepine callysponine |
| title | A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species |
| title_full | A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species |
| title_fullStr | A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species |
| title_full_unstemmed | A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species |
| title_short | A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species |
| title_sort | new 1 4 diazepine from south china sea marine sponge callyspongia species |
| topic | marine sponge Callyspongia sp. diazepine callysponine |
| url | http://www.mdpi.com/1420-3049/15/2/871/ |
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