Analysis of intron sequence features associated with transcriptional regulation in human genes.
Although some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture. In this study, we perform systemic analyses of the sequence characteristics of human introns. The results show that...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3474797?pdf=render |
| _version_ | 1828429775543205888 |
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| author | Huimin Li Dan Chen Jing Zhang |
| author_facet | Huimin Li Dan Chen Jing Zhang |
| author_sort | Huimin Li |
| collection | DOAJ |
| description | Although some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture. In this study, we perform systemic analyses of the sequence characteristics of human introns. The results show that the first introns are generally longer and C, G and their dinucleotide compositions are over-represented relative to other introns, which are consistent with the previous findings. In addition, some new phenomena concerned with transcriptional regulation are found: i) the first introns are enriched in CpG islands; and ii) the percentages of the first introns containing TATA, CAAT and GC boxes are relatively higher than other position introns. The similar features of introns are observed in tissue-specific genes. The results further support that the first introns of human genes are likely to be involved in transcriptional regulation, and give an insight into the transcriptional regulatory regions of genes. |
| first_indexed | 2024-12-10T17:39:08Z |
| format | Article |
| id | doaj.art-1d5d407aa3d841e2a28c1532a63ed7af |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T17:39:08Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1d5d407aa3d841e2a28c1532a63ed7af2022-12-22T01:39:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4678410.1371/journal.pone.0046784Analysis of intron sequence features associated with transcriptional regulation in human genes.Huimin LiDan ChenJing ZhangAlthough some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture. In this study, we perform systemic analyses of the sequence characteristics of human introns. The results show that the first introns are generally longer and C, G and their dinucleotide compositions are over-represented relative to other introns, which are consistent with the previous findings. In addition, some new phenomena concerned with transcriptional regulation are found: i) the first introns are enriched in CpG islands; and ii) the percentages of the first introns containing TATA, CAAT and GC boxes are relatively higher than other position introns. The similar features of introns are observed in tissue-specific genes. The results further support that the first introns of human genes are likely to be involved in transcriptional regulation, and give an insight into the transcriptional regulatory regions of genes.http://europepmc.org/articles/PMC3474797?pdf=render |
| spellingShingle | Huimin Li Dan Chen Jing Zhang Analysis of intron sequence features associated with transcriptional regulation in human genes. PLoS ONE |
| title | Analysis of intron sequence features associated with transcriptional regulation in human genes. |
| title_full | Analysis of intron sequence features associated with transcriptional regulation in human genes. |
| title_fullStr | Analysis of intron sequence features associated with transcriptional regulation in human genes. |
| title_full_unstemmed | Analysis of intron sequence features associated with transcriptional regulation in human genes. |
| title_short | Analysis of intron sequence features associated with transcriptional regulation in human genes. |
| title_sort | analysis of intron sequence features associated with transcriptional regulation in human genes |
| url | http://europepmc.org/articles/PMC3474797?pdf=render |
| work_keys_str_mv | AT huiminli analysisofintronsequencefeaturesassociatedwithtranscriptionalregulationinhumangenes AT danchen analysisofintronsequencefeaturesassociatedwithtranscriptionalregulationinhumangenes AT jingzhang analysisofintronsequencefeaturesassociatedwithtranscriptionalregulationinhumangenes |