Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participants
Parkinson’s disease (PD) is traditionally regarded as a neurodegenerative movement disorder, however, nigrostriatal dopaminergic degeneration is also thought to disrupt non-motor loops connecting basal ganglia to areas in frontal cortex involved in cognition and emotion processing. PD patients are i...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-01-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00349/full |
| _version_ | 1818449221616926720 |
|---|---|
| author | Lindsey G. McIntosh Lindsey G. McIntosh Sishir eMannava Corrie R Camalier Brad S. Folley Aaron eAlbritton Peter E. Konrad David eCharles Sohee ePark Joseph eNeimat |
| author_facet | Lindsey G. McIntosh Lindsey G. McIntosh Sishir eMannava Corrie R Camalier Brad S. Folley Aaron eAlbritton Peter E. Konrad David eCharles Sohee ePark Joseph eNeimat |
| author_sort | Lindsey G. McIntosh |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is traditionally regarded as a neurodegenerative movement disorder, however, nigrostriatal dopaminergic degeneration is also thought to disrupt non-motor loops connecting basal ganglia to areas in frontal cortex involved in cognition and emotion processing. PD patients are impaired on tests of emotion recognition, but it is difficult to disentangle this deficit from the more general cognitive dysfunction that frequently accompanies disease progression. Testing for emotion recognition deficits early in the disease course, prior to cognitive decline, better assesses the sensitivity of these non-motor corticobasal ganglia-thalamocortical loops involved in emotion processing to early degenerative change in basal ganglia circuits. In addition, contrasting this with a group of healthy aging individuals demonstrates changes in emotion processing specific to the degeneration of basal ganglia circuitry in PD. Early PD patients (EPD) were recruited from a randomized clinical trial testing the safety and tolerability of deep brain stimulation of the subthalamic nucleus (STN-DBS) in early-staged PD. EPD patients were previously randomized to receive optimal drug therapy only (ODT), or drug therapy plus STN-DBS (ODT+DBS). Matched healthy elderly controls (HEC) and young controls (HYC) also participated in this study. Participants completed two control tasks and three emotion recognition tests that varied in stimulus domain. EPD patients were impaired on all emotion recognition tasks compared to HEC. Neither therapy type (ODT or ODT+DBS) nor therapy state (ON/OFF) altered emotion recognition performance in this study. Finally, HEC were impaired on vocal emotion recognition relative to HYC, suggesting a decline related to healthy aging. This study supports the existence of impaired emotion recognition early in the PD course, implicating an early disruption of fronto-striatal loops mediating emotional function. |
| first_indexed | 2024-12-14T20:31:58Z |
| format | Article |
| id | doaj.art-1d5d441b540d46dbab96a395f6a2ed7a |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T20:31:58Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-1d5d441b540d46dbab96a395f6a2ed7a2022-12-21T22:48:30ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-01-01610.3389/fnagi.2014.00349104210Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participantsLindsey G. McIntosh0Lindsey G. McIntosh1Sishir eMannava2Corrie R Camalier3Brad S. Folley4Aaron eAlbritton5Peter E. Konrad6David eCharles7Sohee ePark8Joseph eNeimat9Vanderbilt UniversityVanderbilt University Medical CenterVanderbilt University Medical CenterVanderbilt University Medical CenterNorton Neuroscience InstituteVanderbilt University Medical CenterVanderbilt University Medical CenterVanderbilt University Medical CenterVanderbilt UniversityVanderbilt University Medical CenterParkinson’s disease (PD) is traditionally regarded as a neurodegenerative movement disorder, however, nigrostriatal dopaminergic degeneration is also thought to disrupt non-motor loops connecting basal ganglia to areas in frontal cortex involved in cognition and emotion processing. PD patients are impaired on tests of emotion recognition, but it is difficult to disentangle this deficit from the more general cognitive dysfunction that frequently accompanies disease progression. Testing for emotion recognition deficits early in the disease course, prior to cognitive decline, better assesses the sensitivity of these non-motor corticobasal ganglia-thalamocortical loops involved in emotion processing to early degenerative change in basal ganglia circuits. In addition, contrasting this with a group of healthy aging individuals demonstrates changes in emotion processing specific to the degeneration of basal ganglia circuitry in PD. Early PD patients (EPD) were recruited from a randomized clinical trial testing the safety and tolerability of deep brain stimulation of the subthalamic nucleus (STN-DBS) in early-staged PD. EPD patients were previously randomized to receive optimal drug therapy only (ODT), or drug therapy plus STN-DBS (ODT+DBS). Matched healthy elderly controls (HEC) and young controls (HYC) also participated in this study. Participants completed two control tasks and three emotion recognition tests that varied in stimulus domain. EPD patients were impaired on all emotion recognition tasks compared to HEC. Neither therapy type (ODT or ODT+DBS) nor therapy state (ON/OFF) altered emotion recognition performance in this study. Finally, HEC were impaired on vocal emotion recognition relative to HYC, suggesting a decline related to healthy aging. This study supports the existence of impaired emotion recognition early in the PD course, implicating an early disruption of fronto-striatal loops mediating emotional function.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00349/fullDopamineLevodopaemotion recognitionDBShealthy agingearly-stage Parkinson's disease |
| spellingShingle | Lindsey G. McIntosh Lindsey G. McIntosh Sishir eMannava Corrie R Camalier Brad S. Folley Aaron eAlbritton Peter E. Konrad David eCharles Sohee ePark Joseph eNeimat Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participants Frontiers in Aging Neuroscience Dopamine Levodopa emotion recognition DBS healthy aging early-stage Parkinson's disease |
| title | Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participants |
| title_full | Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participants |
| title_fullStr | Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participants |
| title_full_unstemmed | Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participants |
| title_short | Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participants |
| title_sort | emotion recognition in early parkinson 39 s disease patients undergoing deep brain stimulation or dopaminergic therapy a comparison to healthy participants |
| topic | Dopamine Levodopa emotion recognition DBS healthy aging early-stage Parkinson's disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00349/full |
| work_keys_str_mv | AT lindseygmcintosh emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT lindseygmcintosh emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT sishiremannava emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT corriercamalier emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT bradsfolley emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT aaronealbritton emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT peterekonrad emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT davidecharles emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT soheeepark emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants AT josepheneimat emotionrecognitioninearlyparkinson39sdiseasepatientsundergoingdeepbrainstimulationordopaminergictherapyacomparisontohealthyparticipants |