Poly(<i>N</i>-Isopropylacrylamide)-Functional Silicon Nanocrystals for Thermosensitive Fluorescence Cellar Imaging
Silicon nanocrystals (Si NCs) have received surging interest as a type of quantum dot (QD) due to the availability of silicon in nature, tunable fluorescence emission properties and excellent biocompatibility. More importantly, compared with many group II–VI and III–V based QDs, they have low toxici...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/11/2565 |
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| author | Yiting Li Lihui Zhang Youhong Shi Jialing Huang Yaqiong Yang Dengming Ming |
| author_facet | Yiting Li Lihui Zhang Youhong Shi Jialing Huang Yaqiong Yang Dengming Ming |
| author_sort | Yiting Li |
| collection | DOAJ |
| description | Silicon nanocrystals (Si NCs) have received surging interest as a type of quantum dot (QD) due to the availability of silicon in nature, tunable fluorescence emission properties and excellent biocompatibility. More importantly, compared with many group II–VI and III–V based QDs, they have low toxicity. Here, thermoresponsive poly(<i>N</i>-isopropylacrylamide) (PNIPAAm)-functional Si NCs were firstly prepared for thermoresponsive detection of cancer cells. Si NCs were prepared under normal pressure with excellent water solubility. Then folic acid was bonded to the silicon nanocrystals through the reaction of amino and carboxyl groups for specific recognition of cancer cells. The folic-acid-modified silicon crystals (Si NCs-FA) could be modified by a one-pot copolymerization process into PNIPAAm nanospheres during the monomer polymerization process (i.e., Si NCs-FA-PNIPAAm) just by controlling the temperature below the lower critical solution temperature (LCST) and above the LCST. The results showed that the Si-FA-PNIAAm nanospheres exhibited not only reversible temperature-responsive on-off fluorescence properties, but also can be used as temperature indicators in cancer cells. |
| first_indexed | 2024-03-10T15:09:39Z |
| format | Article |
| id | doaj.art-1d5f5d83d87f450ea7b528733e31642b |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T15:09:39Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-1d5f5d83d87f450ea7b528733e31642b2023-11-20T19:25:53ZengMDPI AGPolymers2073-43602020-11-011211256510.3390/polym12112565Poly(<i>N</i>-Isopropylacrylamide)-Functional Silicon Nanocrystals for Thermosensitive Fluorescence Cellar ImagingYiting Li0Lihui Zhang1Youhong Shi2Jialing Huang3Yaqiong Yang4Dengming Ming5College of Food and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, ChinaCollege of Food and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing Tech University, Nanjing 211816, ChinaCollege of Pharmacy, Nanjing Tech University, Nanjing 211816, ChinaCollege of Food and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, ChinaCollege of Biological and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, ChinaSilicon nanocrystals (Si NCs) have received surging interest as a type of quantum dot (QD) due to the availability of silicon in nature, tunable fluorescence emission properties and excellent biocompatibility. More importantly, compared with many group II–VI and III–V based QDs, they have low toxicity. Here, thermoresponsive poly(<i>N</i>-isopropylacrylamide) (PNIPAAm)-functional Si NCs were firstly prepared for thermoresponsive detection of cancer cells. Si NCs were prepared under normal pressure with excellent water solubility. Then folic acid was bonded to the silicon nanocrystals through the reaction of amino and carboxyl groups for specific recognition of cancer cells. The folic-acid-modified silicon crystals (Si NCs-FA) could be modified by a one-pot copolymerization process into PNIPAAm nanospheres during the monomer polymerization process (i.e., Si NCs-FA-PNIPAAm) just by controlling the temperature below the lower critical solution temperature (LCST) and above the LCST. The results showed that the Si-FA-PNIAAm nanospheres exhibited not only reversible temperature-responsive on-off fluorescence properties, but also can be used as temperature indicators in cancer cells.https://www.mdpi.com/2073-4360/12/11/2565silicon nanocrystalsPNIPAAmfluorescent imagingthermoresponsive |
| spellingShingle | Yiting Li Lihui Zhang Youhong Shi Jialing Huang Yaqiong Yang Dengming Ming Poly(<i>N</i>-Isopropylacrylamide)-Functional Silicon Nanocrystals for Thermosensitive Fluorescence Cellar Imaging Polymers silicon nanocrystals PNIPAAm fluorescent imaging thermoresponsive |
| title | Poly(<i>N</i>-Isopropylacrylamide)-Functional Silicon Nanocrystals for Thermosensitive Fluorescence Cellar Imaging |
| title_full | Poly(<i>N</i>-Isopropylacrylamide)-Functional Silicon Nanocrystals for Thermosensitive Fluorescence Cellar Imaging |
| title_fullStr | Poly(<i>N</i>-Isopropylacrylamide)-Functional Silicon Nanocrystals for Thermosensitive Fluorescence Cellar Imaging |
| title_full_unstemmed | Poly(<i>N</i>-Isopropylacrylamide)-Functional Silicon Nanocrystals for Thermosensitive Fluorescence Cellar Imaging |
| title_short | Poly(<i>N</i>-Isopropylacrylamide)-Functional Silicon Nanocrystals for Thermosensitive Fluorescence Cellar Imaging |
| title_sort | poly i n i isopropylacrylamide functional silicon nanocrystals for thermosensitive fluorescence cellar imaging |
| topic | silicon nanocrystals PNIPAAm fluorescent imaging thermoresponsive |
| url | https://www.mdpi.com/2073-4360/12/11/2565 |
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