Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma
Despite increasing knowledge gained based on multidisciplinary research, plasma medicine still raises various questions regarding specific effects as well as potential risks. With regard to significant statements about in vivo applicability that cannot be prognosticated exclusively based on in vitro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/10/4/210 |
| _version_ | 1797570810853982208 |
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| author | Rico Rutkowski Georg Daeschlein Thomas von Woedtke Ralf Smeets Martin Gosau Hans-Robert Metelmann |
| author_facet | Rico Rutkowski Georg Daeschlein Thomas von Woedtke Ralf Smeets Martin Gosau Hans-Robert Metelmann |
| author_sort | Rico Rutkowski |
| collection | DOAJ |
| description | Despite increasing knowledge gained based on multidisciplinary research, plasma medicine still raises various questions regarding specific effects as well as potential risks. With regard to significant statements about in vivo applicability that cannot be prognosticated exclusively based on in vitro data, there is still a deficit of clinical data. This study included a clinical follow-up of five probands who had participated five years previously in a study on the influence of cold atmospheric pressure plasma (CAP) on the wound healing of CO<sub>2</sub> laser-induced skin lesions. The follow-up included a complex imaging diagnostic involving dermatoscopy, confocal laser scanning microscopy (CLSM) and hyperspectral imaging (HSI). Hyperspectral analysis showed no relevant microcirculatory differences between plasma-treated and non-plasma-treated areas. In summary of all the findings, no malignant changes, inflammatory reactions or pathological changes in cell architecture could be detected in the plasma-treated areas. These unique in vivo long-term data contribute to a further increase in knowledge about important safety aspects in regenerative plasma medicine. However, to confirm these findings and secure indication-specific dose recommendations, further clinical studies are required. |
| first_indexed | 2024-03-10T20:31:40Z |
| format | Article |
| id | doaj.art-1d6099e6043a4d74ad2f9e6bfa93ee13 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T20:31:40Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1d6099e6043a4d74ad2f9e6bfa93ee132023-11-19T21:21:54ZengMDPI AGDiagnostics2075-44182020-04-0110421010.3390/diagnostics10040210Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure PlasmaRico Rutkowski0Georg Daeschlein1Thomas von Woedtke2Ralf Smeets3Martin Gosau4Hans-Robert Metelmann5Department of Oral and Maxillofacial Surgery, University Medicine Hamburg-Eppendorf, 20251 Hamburg, GermanyDepartment of Dermatology, University Medicine Greifswald, 17475 Greifswald, GermanyLeibniz Institute for Plasma Science and Technology (INP) e.V. Greifswald, 17489 Greifswald, GermanyDepartment of Oral and Maxillofacial Surgery, University Medicine Hamburg-Eppendorf, 20251 Hamburg, GermanyDepartment of Oral and Maxillofacial Surgery, University Medicine Hamburg-Eppendorf, 20251 Hamburg, GermanyDepartment of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, 17475 Greifswald, GermanyDespite increasing knowledge gained based on multidisciplinary research, plasma medicine still raises various questions regarding specific effects as well as potential risks. With regard to significant statements about in vivo applicability that cannot be prognosticated exclusively based on in vitro data, there is still a deficit of clinical data. This study included a clinical follow-up of five probands who had participated five years previously in a study on the influence of cold atmospheric pressure plasma (CAP) on the wound healing of CO<sub>2</sub> laser-induced skin lesions. The follow-up included a complex imaging diagnostic involving dermatoscopy, confocal laser scanning microscopy (CLSM) and hyperspectral imaging (HSI). Hyperspectral analysis showed no relevant microcirculatory differences between plasma-treated and non-plasma-treated areas. In summary of all the findings, no malignant changes, inflammatory reactions or pathological changes in cell architecture could be detected in the plasma-treated areas. These unique in vivo long-term data contribute to a further increase in knowledge about important safety aspects in regenerative plasma medicine. However, to confirm these findings and secure indication-specific dose recommendations, further clinical studies are required.https://www.mdpi.com/2075-4418/10/4/210wound healingreactive oxygen speciescold atmospheric pressure plasmahyperspectral imagingconfocal laser scanning microscopy |
| spellingShingle | Rico Rutkowski Georg Daeschlein Thomas von Woedtke Ralf Smeets Martin Gosau Hans-Robert Metelmann Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma Diagnostics wound healing reactive oxygen species cold atmospheric pressure plasma hyperspectral imaging confocal laser scanning microscopy |
| title | Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma |
| title_full | Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma |
| title_fullStr | Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma |
| title_full_unstemmed | Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma |
| title_short | Long-Term Risk Assessment for Medical Application of Cold Atmospheric Pressure Plasma |
| title_sort | long term risk assessment for medical application of cold atmospheric pressure plasma |
| topic | wound healing reactive oxygen species cold atmospheric pressure plasma hyperspectral imaging confocal laser scanning microscopy |
| url | https://www.mdpi.com/2075-4418/10/4/210 |
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