Prevalence of high-risk <i>human papillomavirus</i> types 16 and 18 in healthy women with cytologically negative pap smear in Iran
<b>Background:</b> Because <i>human papillomavirus</i> (HPV) is one of the causal factors in cervical cancer, understanding the epidemiology of this infection is an important step towards developing strategies for prevention. <b>Materials and Methods:</b> We evalu...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2010-10-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=4;spage=681;epage=685;aulast=Safaei |
| Summary: | <b>Background:</b> Because <i>human papillomavirus</i> (HPV) is one of the causal factors in cervical cancer, understanding the epidemiology of this infection is an important step towards developing strategies for prevention. <b>Materials and Methods:</b> We evaluated the prevalence of high-risk <i>human papillomavirus</i> Types 16 and 18 in cervical samples from 402 healthy women with normal Pap smears by testing with type-specific primers in the polymerase chain reaction. Participants were seen at two gynecological clinics affiliated to the Shiraz University of Medical Sciences in Iran. <b>Result:</b> The prevalence of positive HPV findings was 5.5%; high-risk HPV <i>human papillomavirus</i> Type 16 prevalence was 2% and no patient harbored HPV-18. The prevalence of HPV was 4.5% in younger age group and gradually increased to 20% in the 4 <sup>th</sup> decade. <b>Conclusion:</b> The prevalence of high-risk HPV was highest in the youngest women and gradually decreased with age. Overall, the prevalence of HPV in our population is low. |
|---|---|
| ISSN: | 0377-4929 0974-5130 |