Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis
Rheumatoid nodules (RNs) are one of the most common extra-articular manifestations of rheumatoid arthritis (RA), but are rarely located in lung tissue. The development of extra-articular (systemic) manifestations of RA is associated with the high levels of rheumatoid factor and anticyclic citrullina...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2019-07-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2738 |
| _version_ | 1797862631019642880 |
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| author | A. M. Satybaldyev L. P. Ananyeva |
| author_facet | A. M. Satybaldyev L. P. Ananyeva |
| author_sort | A. M. Satybaldyev |
| collection | DOAJ |
| description | Rheumatoid nodules (RNs) are one of the most common extra-articular manifestations of rheumatoid arthritis (RA), but are rarely located in lung tissue. The development of extra-articular (systemic) manifestations of RA is associated with the high levels of rheumatoid factor and anticyclic citrullinated peptide antibodies. The specific features of the course of RNs in lung tissue are their frequent occurrence with minimally pronounced joint inflammatory changes or remission. In rare cases, RNs are prone to disintegration and suppuration, which may be complicated by the formation of small caverns, hemoptysis, and, if located subpleurally, pneumothorax. In addition, there are publications on the possible relationship of the formation of RNs and their accelerated development to the administration of immunosuppressive drugs (methotrexate, tocilizumab, D-penicillamine, gold salts, leflunomide, infliximab, and other TNF-α inhibitors) and on the association of pulmonary RNs with methotrexate treatment. The paper describes a clinical case of a female patient with RA-systemic sclerosis overlap syndrome and RN formation in lung tissue early at disease onset when the DAS28 target level for RA has been achieved. The atypical outline of a pulmonary nodule has required a differential diagnostic search. The results of imaging RNs in the lung and their dynamics are shown. The given data are discussed. |
| first_indexed | 2024-04-09T22:22:28Z |
| format | Article |
| id | doaj.art-1d61995a65e44244be658ab1e23506f3 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:22:28Z |
| publishDate | 2019-07-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-1d61995a65e44244be658ab1e23506f32023-03-22T13:45:55ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922019-07-0157334935510.14412/1995-4484-2019-349-3552502Rheumatoid nodules in the lung parenchyma in rheumatoid arthritisA. M. Satybaldyev0L. P. Ananyeva1V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyRheumatoid nodules (RNs) are one of the most common extra-articular manifestations of rheumatoid arthritis (RA), but are rarely located in lung tissue. The development of extra-articular (systemic) manifestations of RA is associated with the high levels of rheumatoid factor and anticyclic citrullinated peptide antibodies. The specific features of the course of RNs in lung tissue are their frequent occurrence with minimally pronounced joint inflammatory changes or remission. In rare cases, RNs are prone to disintegration and suppuration, which may be complicated by the formation of small caverns, hemoptysis, and, if located subpleurally, pneumothorax. In addition, there are publications on the possible relationship of the formation of RNs and their accelerated development to the administration of immunosuppressive drugs (methotrexate, tocilizumab, D-penicillamine, gold salts, leflunomide, infliximab, and other TNF-α inhibitors) and on the association of pulmonary RNs with methotrexate treatment. The paper describes a clinical case of a female patient with RA-systemic sclerosis overlap syndrome and RN formation in lung tissue early at disease onset when the DAS28 target level for RA has been achieved. The atypical outline of a pulmonary nodule has required a differential diagnostic search. The results of imaging RNs in the lung and their dynamics are shown. The given data are discussed.https://rsp.mediar-press.net/rsp/article/view/2738rheumatoid arthritisoverlap syndromesystemic sclerosisextra-articular manifestationsrheumatoid nodulesmethotrexateleflunomidesulfasalazinepulmonary nodules |
| spellingShingle | A. M. Satybaldyev L. P. Ananyeva Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis Научно-практическая ревматология rheumatoid arthritis overlap syndrome systemic sclerosis extra-articular manifestations rheumatoid nodules methotrexate leflunomide sulfasalazine pulmonary nodules |
| title | Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis |
| title_full | Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis |
| title_fullStr | Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis |
| title_full_unstemmed | Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis |
| title_short | Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis |
| title_sort | rheumatoid nodules in the lung parenchyma in rheumatoid arthritis |
| topic | rheumatoid arthritis overlap syndrome systemic sclerosis extra-articular manifestations rheumatoid nodules methotrexate leflunomide sulfasalazine pulmonary nodules |
| url | https://rsp.mediar-press.net/rsp/article/view/2738 |
| work_keys_str_mv | AT amsatybaldyev rheumatoidnodulesinthelungparenchymainrheumatoidarthritis AT lpananyeva rheumatoidnodulesinthelungparenchymainrheumatoidarthritis |