The Effect of Synbiotic Consumption on Serum NTproBNP, hsCRP and Blood Pressure in Patients With Chronic Heart Failure: A Randomized, Triple-Blind, Controlled Trial
BackgroundIn recent years, there has been a positive attitude toward gut microbiota and its effect on cardiovascular diseases, including heart failure.ObjectiveThe purpose of this study was to evaluate the effect of synbiotics on left ventricular hypertrophy by measuring NT-proBNP, and their effect...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.822498/full |
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| author | Shakiba Shoaei Matin Farzad Shidfar Nasim Naderi Ahmad Amin Fatemeh Sadat Hosseini-Baharanchi Afsaneh Dehnad |
| author_facet | Shakiba Shoaei Matin Farzad Shidfar Nasim Naderi Ahmad Amin Fatemeh Sadat Hosseini-Baharanchi Afsaneh Dehnad |
| author_sort | Shakiba Shoaei Matin |
| collection | DOAJ |
| description | BackgroundIn recent years, there has been a positive attitude toward gut microbiota and its effect on cardiovascular diseases, including heart failure.ObjectiveThe purpose of this study was to evaluate the effect of synbiotics on left ventricular hypertrophy by measuring NT-proBNP, and their effect on blood pressure and hsCRP as an inflammatory biomarker in patients with chronic heart failure.DesignIn this triple-blind randomized clinical trial, 90 eligible patients were included in the study. They were randomly assigned to receive one capsule (500 mg) of synbiotics or placebo per day for 10 weeks. NTproBNP, hsCRP and blood pressure were measured at the beginning and end of the study. Statistical analysis was performed on 80 patients by using SPSS 24, and p < 0.05 as statistically significant.ResultAt the end of the study, the level of NT-proBNP decreased significantly in the synbiotic group compared to the placebo group (r = −256.55; P = 0.04). However, hsCRP increased in both groups as compared to the beginning of the study, but only in the placebo group the increase in hsCRP was significant (P = 0.01). The results showed that the changes in hs-CRP was not significant between the two groups. No statistically significant differences were observed in systolic and diastolic blood pressure between the two groups at the end of the intervention.ConclusionSynbiotics have favorable effect on cardiac hypertrophy index (NT-proBNP). Although the inflammatory factor increased in both groups, the significant increase in hsCRP in the placebo group could indicate the beneficial effects of synbiotics on the inflammatory status of these patients.Clinical Trial Registrationhttps://en.irct.ir/user/trial/42905/view, identifier: IRCT20091114002709N52. |
| first_indexed | 2024-12-12T21:41:48Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-12T21:41:48Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-1d62b79cee6e441897b6cf15b7ebe4132022-12-22T00:11:01ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-04-01810.3389/fnut.2021.822498822498The Effect of Synbiotic Consumption on Serum NTproBNP, hsCRP and Blood Pressure in Patients With Chronic Heart Failure: A Randomized, Triple-Blind, Controlled TrialShakiba Shoaei Matin0Farzad Shidfar1Nasim Naderi2Ahmad Amin3Fatemeh Sadat Hosseini-Baharanchi4Afsaneh Dehnad5Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, IranDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, IranDepartment of Biostatistics, Minimally Invasive Surgery Research Center, School of Public Health, Iran University of Medical Sciences, Tehran, IranDepartment of Medical Education, Center for Educational Research in Medical Sciences (CERMS), School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, IranBackgroundIn recent years, there has been a positive attitude toward gut microbiota and its effect on cardiovascular diseases, including heart failure.ObjectiveThe purpose of this study was to evaluate the effect of synbiotics on left ventricular hypertrophy by measuring NT-proBNP, and their effect on blood pressure and hsCRP as an inflammatory biomarker in patients with chronic heart failure.DesignIn this triple-blind randomized clinical trial, 90 eligible patients were included in the study. They were randomly assigned to receive one capsule (500 mg) of synbiotics or placebo per day for 10 weeks. NTproBNP, hsCRP and blood pressure were measured at the beginning and end of the study. Statistical analysis was performed on 80 patients by using SPSS 24, and p < 0.05 as statistically significant.ResultAt the end of the study, the level of NT-proBNP decreased significantly in the synbiotic group compared to the placebo group (r = −256.55; P = 0.04). However, hsCRP increased in both groups as compared to the beginning of the study, but only in the placebo group the increase in hsCRP was significant (P = 0.01). The results showed that the changes in hs-CRP was not significant between the two groups. No statistically significant differences were observed in systolic and diastolic blood pressure between the two groups at the end of the intervention.ConclusionSynbiotics have favorable effect on cardiac hypertrophy index (NT-proBNP). Although the inflammatory factor increased in both groups, the significant increase in hsCRP in the placebo group could indicate the beneficial effects of synbiotics on the inflammatory status of these patients.Clinical Trial Registrationhttps://en.irct.ir/user/trial/42905/view, identifier: IRCT20091114002709N52.https://www.frontiersin.org/articles/10.3389/fnut.2021.822498/fullsynbioticheart failureNT-proBNPblood pressurehs-CRP |
| spellingShingle | Shakiba Shoaei Matin Farzad Shidfar Nasim Naderi Ahmad Amin Fatemeh Sadat Hosseini-Baharanchi Afsaneh Dehnad The Effect of Synbiotic Consumption on Serum NTproBNP, hsCRP and Blood Pressure in Patients With Chronic Heart Failure: A Randomized, Triple-Blind, Controlled Trial Frontiers in Nutrition synbiotic heart failure NT-proBNP blood pressure hs-CRP |
| title | The Effect of Synbiotic Consumption on Serum NTproBNP, hsCRP and Blood Pressure in Patients With Chronic Heart Failure: A Randomized, Triple-Blind, Controlled Trial |
| title_full | The Effect of Synbiotic Consumption on Serum NTproBNP, hsCRP and Blood Pressure in Patients With Chronic Heart Failure: A Randomized, Triple-Blind, Controlled Trial |
| title_fullStr | The Effect of Synbiotic Consumption on Serum NTproBNP, hsCRP and Blood Pressure in Patients With Chronic Heart Failure: A Randomized, Triple-Blind, Controlled Trial |
| title_full_unstemmed | The Effect of Synbiotic Consumption on Serum NTproBNP, hsCRP and Blood Pressure in Patients With Chronic Heart Failure: A Randomized, Triple-Blind, Controlled Trial |
| title_short | The Effect of Synbiotic Consumption on Serum NTproBNP, hsCRP and Blood Pressure in Patients With Chronic Heart Failure: A Randomized, Triple-Blind, Controlled Trial |
| title_sort | effect of synbiotic consumption on serum ntprobnp hscrp and blood pressure in patients with chronic heart failure a randomized triple blind controlled trial |
| topic | synbiotic heart failure NT-proBNP blood pressure hs-CRP |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.822498/full |
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