Seroprevalence of hepatitis B viral infection in the okpoko community
Background: Hepatitis B virus infection (HBV) is a potentially life-threatening liver infection. Little is known about seroprevalence at the community level. A cross-sectional, community-based study was conducted at Okopko, an urban slum in Ogbaru Local Government Area of Anambra State, Nigeria, usi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Biomedical and Biotechnology Research Journal |
| Subjects: | |
| Online Access: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=3;spage=454;epage=457;aulast=Nwachukwu |
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| author | Ndubuisi Obiora Nwachukwu Christopher Uche Okoronkwo Precious Ndudi Duru |
| author_facet | Ndubuisi Obiora Nwachukwu Christopher Uche Okoronkwo Precious Ndudi Duru |
| author_sort | Ndubuisi Obiora Nwachukwu |
| collection | DOAJ |
| description | Background: Hepatitis B virus infection (HBV) is a potentially life-threatening liver infection. Little is known about seroprevalence at the community level. A cross-sectional, community-based study was conducted at Okopko, an urban slum in Ogbaru Local Government Area of Anambra State, Nigeria, using a multistage sampling technique. Stages were the constituency level, ward, and household levels. A total of 867 participants were enrolled. Methods: Testing for the markers of HBV was performed using Diagnostic Kit (USA). The test panel detects hepatitis B surface antigen (HBsAg), hepatitis e antigen (HBeAg), antibody to e antigen (HBeAb), core antibody (HBcAb), and surface antibody (HBsAb) using colloidal gold and membrane chromatographic technology. Results: The seroprevalence of HBsAg was 6.6%. Seroprevalence was higher in males (7.4%) than in females (5.5%) (P > 0.05). The peak seroprevalence occurred in the age group of 40–49 years for both males (13.6%) and females (8.1%) (P < 0.05). Exactly 4.7% were positive for HBeAg and 5.8% for HBsAg + HBeAg + HBcAb. Only 1% was positive for HBsAb. Conclusion: Okpoko community has a high intermediate prevalence rate of HBV infection. The HBV vaccination level is very low in the community. |
| first_indexed | 2024-04-14T00:06:28Z |
| format | Article |
| id | doaj.art-1d636abe63e74408aa7e081f71d7c89f |
| institution | Directory Open Access Journal |
| issn | 2588-9834 2588-9842 |
| language | English |
| last_indexed | 2024-04-14T00:06:28Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical and Biotechnology Research Journal |
| spelling | doaj.art-1d636abe63e74408aa7e081f71d7c89f2022-12-22T02:23:31ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342588-98422022-01-016345445710.4103/bbrj.bbrj_85_22Seroprevalence of hepatitis B viral infection in the okpoko communityNdubuisi Obiora NwachukwuChristopher Uche OkoronkwoPrecious Ndudi DuruBackground: Hepatitis B virus infection (HBV) is a potentially life-threatening liver infection. Little is known about seroprevalence at the community level. A cross-sectional, community-based study was conducted at Okopko, an urban slum in Ogbaru Local Government Area of Anambra State, Nigeria, using a multistage sampling technique. Stages were the constituency level, ward, and household levels. A total of 867 participants were enrolled. Methods: Testing for the markers of HBV was performed using Diagnostic Kit (USA). The test panel detects hepatitis B surface antigen (HBsAg), hepatitis e antigen (HBeAg), antibody to e antigen (HBeAb), core antibody (HBcAb), and surface antibody (HBsAb) using colloidal gold and membrane chromatographic technology. Results: The seroprevalence of HBsAg was 6.6%. Seroprevalence was higher in males (7.4%) than in females (5.5%) (P > 0.05). The peak seroprevalence occurred in the age group of 40–49 years for both males (13.6%) and females (8.1%) (P < 0.05). Exactly 4.7% were positive for HBeAg and 5.8% for HBsAg + HBeAg + HBcAb. Only 1% was positive for HBsAb. Conclusion: Okpoko community has a high intermediate prevalence rate of HBV infection. The HBV vaccination level is very low in the community.http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=3;spage=454;epage=457;aulast=Nwachukwuhepatitis bviral infectionseroprevalencenigeria |
| spellingShingle | Ndubuisi Obiora Nwachukwu Christopher Uche Okoronkwo Precious Ndudi Duru Seroprevalence of hepatitis B viral infection in the okpoko community Biomedical and Biotechnology Research Journal hepatitis b viral infection seroprevalence nigeria |
| title | Seroprevalence of hepatitis B viral infection in the okpoko community |
| title_full | Seroprevalence of hepatitis B viral infection in the okpoko community |
| title_fullStr | Seroprevalence of hepatitis B viral infection in the okpoko community |
| title_full_unstemmed | Seroprevalence of hepatitis B viral infection in the okpoko community |
| title_short | Seroprevalence of hepatitis B viral infection in the okpoko community |
| title_sort | seroprevalence of hepatitis b viral infection in the okpoko community |
| topic | hepatitis b viral infection seroprevalence nigeria |
| url | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=3;spage=454;epage=457;aulast=Nwachukwu |
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