Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic
The American Cancer Society estimated around 61,090 new cases of leukemia were diagnosed, and around 23,660 people died from this disease in the United States alone in 2021. Due to its burden on society, there is an unmet need to explore innovative approaches to overcome leukemia. Among different st...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Biotechnology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X22000157 |
| _version_ | 1818213955462496256 |
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| author | Ebrahim Mostafavi Atefeh Zarepour Hamed Barabadi Ali Zarrabi Linh B. Truong David Medina-Cruz |
| author_facet | Ebrahim Mostafavi Atefeh Zarepour Hamed Barabadi Ali Zarrabi Linh B. Truong David Medina-Cruz |
| author_sort | Ebrahim Mostafavi |
| collection | DOAJ |
| description | The American Cancer Society estimated around 61,090 new cases of leukemia were diagnosed, and around 23,660 people died from this disease in the United States alone in 2021. Due to its burden on society, there is an unmet need to explore innovative approaches to overcome leukemia. Among different strategies that have been explored, nanotechnology appears to be a promising and effective approach for therapeutics. Specifically, biogenic silver and gold nanoparticles (NPs) have attracted significant attention for their antineoplastic activity toward leukemia cancer cells due to their unique physicochemical properties. Indeed, these nanostructures have emerged as useful approaches in anti-leukemic applications, either as carriers to enhance drug bioavailability and its targeted delivery to a specific organ or as a novel therapeutic agent. This review explores recent advances in green synthesized nanomaterials and their potential use against leukemia, especially focusing on silver (Ag) and gold (Au) nanostructures. In detail, we have reviewed various eco-friendly methods of bio-synthesized NPs, their analytical properties, and toxicity effects against leukemic models. This overview confirms the satisfactory potency of biogenic NPs toward leukemic cells and desirable safety profiles against human native cells, which opens a promising door toward commercializing these types of nontherapeutic agents if challenges involve clinical validations, reproducibility, and scalability could be resolved. |
| first_indexed | 2024-12-12T06:12:31Z |
| format | Article |
| id | doaj.art-1d6521338d784ef9b24df3e66a956c4b |
| institution | Directory Open Access Journal |
| issn | 2215-017X |
| language | English |
| last_indexed | 2024-12-12T06:12:31Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj.art-1d6521338d784ef9b24df3e66a956c4b2022-12-22T00:35:07ZengElsevierBiotechnology Reports2215-017X2022-06-0134e00714Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnosticEbrahim Mostafavi0Atefeh Zarepour1Hamed Barabadi2Ali Zarrabi3Linh B. Truong4David Medina-Cruz5Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Corresponding author.Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer, Istanbul 34396, TurkeyDepartment of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer, Istanbul 34396, TurkeyDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USADepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USAThe American Cancer Society estimated around 61,090 new cases of leukemia were diagnosed, and around 23,660 people died from this disease in the United States alone in 2021. Due to its burden on society, there is an unmet need to explore innovative approaches to overcome leukemia. Among different strategies that have been explored, nanotechnology appears to be a promising and effective approach for therapeutics. Specifically, biogenic silver and gold nanoparticles (NPs) have attracted significant attention for their antineoplastic activity toward leukemia cancer cells due to their unique physicochemical properties. Indeed, these nanostructures have emerged as useful approaches in anti-leukemic applications, either as carriers to enhance drug bioavailability and its targeted delivery to a specific organ or as a novel therapeutic agent. This review explores recent advances in green synthesized nanomaterials and their potential use against leukemia, especially focusing on silver (Ag) and gold (Au) nanostructures. In detail, we have reviewed various eco-friendly methods of bio-synthesized NPs, their analytical properties, and toxicity effects against leukemic models. This overview confirms the satisfactory potency of biogenic NPs toward leukemic cells and desirable safety profiles against human native cells, which opens a promising door toward commercializing these types of nontherapeutic agents if challenges involve clinical validations, reproducibility, and scalability could be resolved.http://www.sciencedirect.com/science/article/pii/S2215017X22000157BiosynthesisMetallic nanomaterialsGold NPssSilver NPsTherapeuticLeukemia |
| spellingShingle | Ebrahim Mostafavi Atefeh Zarepour Hamed Barabadi Ali Zarrabi Linh B. Truong David Medina-Cruz Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic Biotechnology Reports Biosynthesis Metallic nanomaterials Gold NPss Silver NPs Therapeutic Leukemia |
| title | Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic |
| title_full | Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic |
| title_fullStr | Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic |
| title_full_unstemmed | Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic |
| title_short | Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic |
| title_sort | antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia beginning a new era in cancer theragnostic |
| topic | Biosynthesis Metallic nanomaterials Gold NPss Silver NPs Therapeutic Leukemia |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X22000157 |
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