Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Introduction: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Due to the limited understanding of this disease, research has quickly extended towards identifying biomarkers to predict its prognosis and progression....
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2024-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/19236/68774_CE[Ra1]_F(SHU)_QC(PS_RDW_IS)_PF1(AG_OM)_PFA(AG_KM)_PN(KM).pdf |
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| author | Bonchanpalli Mohan Kumar Mustahsin Malik Rajesh Kumar |
| author_facet | Bonchanpalli Mohan Kumar Mustahsin Malik Rajesh Kumar |
| author_sort | Bonchanpalli Mohan Kumar |
| collection | DOAJ |
| description | Introduction: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Due to the limited understanding of this disease, research has quickly extended towards identifying biomarkers to predict its prognosis and progression.
Aim: To explore the impact of albumin infusion on critically ill COVID-19 patients.
Materials and Methods: In this retrospective cohort study, a total of 150 severe COVID-19 patients aged 18 to 65 years were enrolled. These patients were categorised into the no albumin infusion group (n=61), consisting of those who did not undergo albumin transfusion during their treatment, and the albumin infusion group (n=89), comprising patients who received albumin transfusion as part of their treatment protocol. Assessments of hospitalisation included the Sequential Organ Failure Assessment (SOFA), and Acute Physiology and Chronic Health Evaluation (APACHE-II) scores obtained at baseline and day 5. Unpaired t-tests, Chi-square tests, and paired t-tests were used for analysis.
Results: The mean values of Haemoglobin (Hb), eosinophils, Random Blood Sugar (RBS), Mean Corpuscular Volume (MCV), total protein, serum urea, serum bilirubin, Prothrombin Time (PT), International Normalised Ratio (INR), Interleukin 6 (IL-6), Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and D-dimer exhibited significant differences between the two groups. The average duration of vasopressor usage and Intensive Care Unit (ICU) stay were significantly reduced in the albumin infusion group (3.50±1.55 days and 8.70±4.20 days, respectively) compared to no albumin infusion group (4.33±1.05 days and 12.80±3.43 days, respectively). The albumin infusion group also displayed a lower incidence of Renal Replacement Therapy (RRT) and poorer ICU outcomes.
Conclusion: The intravenous administration of albumin did not exhibit a significant impact on mortality. However, albumin transfusion in patients with severe COVID-19 who initially had albumin levels <3 g/dL demonstrated a notable reduction in the requirement for vasopressors, RRT, and the length of ICU stay. |
| first_indexed | 2024-04-24T21:59:41Z |
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| id | doaj.art-1d65893bc1cd40b987d75bdcf442e9e6 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-24T21:59:41Z |
| publishDate | 2024-04-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-1d65893bc1cd40b987d75bdcf442e9e62024-03-20T12:05:02ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-04-011804121610.7860/JCDR/2024/68774.19236Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort StudyBonchanpalli Mohan Kumar0Mustahsin Malik1Rajesh Kumar2Junior Resident, Department of Critical Care Unit and Anaesthesiology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.Professor, Department of Critical Care Unit and Anaesthesiology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.Assistant Professor, Department of Critical Care Unit and Anaesthesiology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.Introduction: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Due to the limited understanding of this disease, research has quickly extended towards identifying biomarkers to predict its prognosis and progression. Aim: To explore the impact of albumin infusion on critically ill COVID-19 patients. Materials and Methods: In this retrospective cohort study, a total of 150 severe COVID-19 patients aged 18 to 65 years were enrolled. These patients were categorised into the no albumin infusion group (n=61), consisting of those who did not undergo albumin transfusion during their treatment, and the albumin infusion group (n=89), comprising patients who received albumin transfusion as part of their treatment protocol. Assessments of hospitalisation included the Sequential Organ Failure Assessment (SOFA), and Acute Physiology and Chronic Health Evaluation (APACHE-II) scores obtained at baseline and day 5. Unpaired t-tests, Chi-square tests, and paired t-tests were used for analysis. Results: The mean values of Haemoglobin (Hb), eosinophils, Random Blood Sugar (RBS), Mean Corpuscular Volume (MCV), total protein, serum urea, serum bilirubin, Prothrombin Time (PT), International Normalised Ratio (INR), Interleukin 6 (IL-6), Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and D-dimer exhibited significant differences between the two groups. The average duration of vasopressor usage and Intensive Care Unit (ICU) stay were significantly reduced in the albumin infusion group (3.50±1.55 days and 8.70±4.20 days, respectively) compared to no albumin infusion group (4.33±1.05 days and 12.80±3.43 days, respectively). The albumin infusion group also displayed a lower incidence of Renal Replacement Therapy (RRT) and poorer ICU outcomes. Conclusion: The intravenous administration of albumin did not exhibit a significant impact on mortality. However, albumin transfusion in patients with severe COVID-19 who initially had albumin levels <3 g/dL demonstrated a notable reduction in the requirement for vasopressors, RRT, and the length of ICU stay.https://www.jcdr.net/articles/PDF/19236/68774_CE[Ra1]_F(SHU)_QC(PS_RDW_IS)_PF1(AG_OM)_PFA(AG_KM)_PN(KM).pdfalbumin infusionhypoalbuminemiaintensive care unit staymortalityvasopressor |
| spellingShingle | Bonchanpalli Mohan Kumar Mustahsin Malik Rajesh Kumar Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort Study Journal of Clinical and Diagnostic Research albumin infusion hypoalbuminemia intensive care unit stay mortality vasopressor |
| title | Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort Study |
| title_full | Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort Study |
| title_fullStr | Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort Study |
| title_full_unstemmed | Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort Study |
| title_short | Impact of Albumin Therapy in Critically Ill COVID-19 Patients: A Retrospective Cohort Study |
| title_sort | impact of albumin therapy in critically ill covid 19 patients a retrospective cohort study |
| topic | albumin infusion hypoalbuminemia intensive care unit stay mortality vasopressor |
| url | https://www.jcdr.net/articles/PDF/19236/68774_CE[Ra1]_F(SHU)_QC(PS_RDW_IS)_PF1(AG_OM)_PFA(AG_KM)_PN(KM).pdf |
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