Incidence and Risk Factors of Venous Thromboembolism in Patients with Lung Adenocarcinoma Receiving Anti-tumor Therapy
Background and objective Venous thromboembolism (VTE) as the most common cancer-associated complication has become the second death-causing reason among cancer patients. The management of VTE in patients with lung adenocarcinoma should focus on early and timely detection of risk factors. The aim of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2023-06-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.22 |
| _version_ | 1797773256022818816 |
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| author | Xing CHEN Weiping XIE Chaoli YUE Ting TANG Yuchuyuan SUN Kouying LIU |
| author_facet | Xing CHEN Weiping XIE Chaoli YUE Ting TANG Yuchuyuan SUN Kouying LIU |
| author_sort | Xing CHEN |
| collection | DOAJ |
| description | Background and objective Venous thromboembolism (VTE) as the most common cancer-associated complication has become the second death-causing reason among cancer patients. The management of VTE in patients with lung adenocarcinoma should focus on early and timely detection of risk factors. The aim of the study is to investigate the current situation of VTE in patients with lung adenocarcinoma treated with anti-tumor therapy and then explore the risk factors associated with the occurrence of VTE during anti-tumor therapy for early detection and screening of VTE. Methods The present study included patients diagnosed as lung adenocarcinoma undergoing anti-tumor therapy in First Affiliated Hospital of Nanjing Medical University between December 2019 and May 2021. The risk factors were identified via univariate and multivariate Cox analysis. The incidence of independent risk factors were investigated through Kaplan-Meier curves combined with Log-rank test. Results The results of univariate and multivariate Cox regression showed that history of VTE, targeted therapy and radiotherapy were risk factors for VTE in patients with lung adenocarcinoma treated with anti-tumor therapy (P<0.05). Furthermore, the results of Kaplan-Meier curves and Log-rank tests indicated the incidences of VTE in patients with history of VTE, targeted therapy and radiotherapy were higher (P<0.05). Conclusion History of VTE, radiotherapy and targeted therapy are found as independent risk factors for the occurrence of VTE, which should be identified and monitored for reduction of VTE incidence. |
| first_indexed | 2024-03-12T22:02:46Z |
| format | Article |
| id | doaj.art-1d6894d23c124b55b4657f2c4250b807 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-03-12T22:02:46Z |
| publishDate | 2023-06-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-1d6894d23c124b55b4657f2c4250b8072023-07-25T01:53:49ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872023-06-0126643944810.3779/j.issn.1009-3419.2023.102.22Incidence and Risk Factors of Venous Thromboembolism in Patients
with Lung Adenocarcinoma Receiving Anti-tumor TherapyXing CHEN0Weiping XIE1Chaoli YUE2Ting TANG3Yuchuyuan SUN4Kouying LIU5Department of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaBackground and objective Venous thromboembolism (VTE) as the most common cancer-associated complication has become the second death-causing reason among cancer patients. The management of VTE in patients with lung adenocarcinoma should focus on early and timely detection of risk factors. The aim of the study is to investigate the current situation of VTE in patients with lung adenocarcinoma treated with anti-tumor therapy and then explore the risk factors associated with the occurrence of VTE during anti-tumor therapy for early detection and screening of VTE. Methods The present study included patients diagnosed as lung adenocarcinoma undergoing anti-tumor therapy in First Affiliated Hospital of Nanjing Medical University between December 2019 and May 2021. The risk factors were identified via univariate and multivariate Cox analysis. The incidence of independent risk factors were investigated through Kaplan-Meier curves combined with Log-rank test. Results The results of univariate and multivariate Cox regression showed that history of VTE, targeted therapy and radiotherapy were risk factors for VTE in patients with lung adenocarcinoma treated with anti-tumor therapy (P<0.05). Furthermore, the results of Kaplan-Meier curves and Log-rank tests indicated the incidences of VTE in patients with history of VTE, targeted therapy and radiotherapy were higher (P<0.05). Conclusion History of VTE, radiotherapy and targeted therapy are found as independent risk factors for the occurrence of VTE, which should be identified and monitored for reduction of VTE incidence.http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.22lung neoplasmsvenous thromboembolismantitumor therapyrisk factors |
| spellingShingle | Xing CHEN Weiping XIE Chaoli YUE Ting TANG Yuchuyuan SUN Kouying LIU Incidence and Risk Factors of Venous Thromboembolism in Patients with Lung Adenocarcinoma Receiving Anti-tumor Therapy Chinese Journal of Lung Cancer lung neoplasms venous thromboembolism antitumor therapy risk factors |
| title | Incidence and Risk Factors of Venous Thromboembolism in Patients
with Lung Adenocarcinoma Receiving Anti-tumor Therapy |
| title_full | Incidence and Risk Factors of Venous Thromboembolism in Patients
with Lung Adenocarcinoma Receiving Anti-tumor Therapy |
| title_fullStr | Incidence and Risk Factors of Venous Thromboembolism in Patients
with Lung Adenocarcinoma Receiving Anti-tumor Therapy |
| title_full_unstemmed | Incidence and Risk Factors of Venous Thromboembolism in Patients
with Lung Adenocarcinoma Receiving Anti-tumor Therapy |
| title_short | Incidence and Risk Factors of Venous Thromboembolism in Patients
with Lung Adenocarcinoma Receiving Anti-tumor Therapy |
| title_sort | incidence and risk factors of venous thromboembolism in patients
with lung adenocarcinoma receiving anti tumor therapy |
| topic | lung neoplasms venous thromboembolism antitumor therapy risk factors |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.22 |
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