Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal
Cancer stem cells (CSCs) are undifferentiated cells that give rise to tumor and resistance to chemotherapy. This study reports that phenylacetaldehyde (PAA), a flower flavor, inhibits formation on breast CSCs. PAA showed anti-proliferation and increased apoptosis of breast cancer. PAA also reduced t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/11/1119 |
| _version_ | 1827702311383728128 |
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| author | Hack Sun Choi Su-Lim Kim Ji-Hyang Kim Yu-Chan Ko Dong-Sun Lee |
| author_facet | Hack Sun Choi Su-Lim Kim Ji-Hyang Kim Yu-Chan Ko Dong-Sun Lee |
| author_sort | Hack Sun Choi |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) are undifferentiated cells that give rise to tumor and resistance to chemotherapy. This study reports that phenylacetaldehyde (PAA), a flower flavor, inhibits formation on breast CSCs. PAA showed anti-proliferation and increased apoptosis of breast cancer. PAA also reduced tumor growth in an in vivo mice model. PAA reduced the CD44<sup>+</sup>/CD24<sup>−</sup> and ALDH1-expressing cells, mammosphere formation, and CSC marker genes. PAA preferentially induced reactive oxygen species (ROS) production and combined treatment with PAA and N-acetyl cysteine (NAC) decreased inhibition of mammosphere formation. PAA reduced phosphorylation of nuclear Stat3. PAA inhibited Stat3 signaling through de-phosphorylation of Stat3 and reduced secretory IL-6. Our results suggest that the PAA-induced ROS deregulated Stat3/IL-6 pathway and PAA may be a potential agent targeting breast cancer and CSCs. |
| first_indexed | 2024-03-10T14:52:35Z |
| format | Article |
| id | doaj.art-1d68c13cfdc04bb584c5d9db419de6f8 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T14:52:35Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1d68c13cfdc04bb584c5d9db419de6f82023-11-20T20:49:01ZengMDPI AGAntioxidants2076-39212020-11-01911111910.3390/antiox9111119Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 SignalHack Sun Choi0Su-Lim Kim1Ji-Hyang Kim2Yu-Chan Ko3Dong-Sun Lee4Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju 63243, KoreaInterdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, KoreaInterdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, KoreaInterdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, KoreaSubtropical/Tropical Organism Gene Bank, Jeju National University, Jeju 63243, KoreaCancer stem cells (CSCs) are undifferentiated cells that give rise to tumor and resistance to chemotherapy. This study reports that phenylacetaldehyde (PAA), a flower flavor, inhibits formation on breast CSCs. PAA showed anti-proliferation and increased apoptosis of breast cancer. PAA also reduced tumor growth in an in vivo mice model. PAA reduced the CD44<sup>+</sup>/CD24<sup>−</sup> and ALDH1-expressing cells, mammosphere formation, and CSC marker genes. PAA preferentially induced reactive oxygen species (ROS) production and combined treatment with PAA and N-acetyl cysteine (NAC) decreased inhibition of mammosphere formation. PAA reduced phosphorylation of nuclear Stat3. PAA inhibited Stat3 signaling through de-phosphorylation of Stat3 and reduced secretory IL-6. Our results suggest that the PAA-induced ROS deregulated Stat3/IL-6 pathway and PAA may be a potential agent targeting breast cancer and CSCs.https://www.mdpi.com/2076-3921/9/11/1119cancer stem cells (CSCs)phenylacetaldehyde (PAA)breast cancerStat3ROS |
| spellingShingle | Hack Sun Choi Su-Lim Kim Ji-Hyang Kim Yu-Chan Ko Dong-Sun Lee Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal Antioxidants cancer stem cells (CSCs) phenylacetaldehyde (PAA) breast cancer Stat3 ROS |
| title | Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal |
| title_full | Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal |
| title_fullStr | Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal |
| title_full_unstemmed | Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal |
| title_short | Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal |
| title_sort | plant volatile phenylacetaldehyde targets breast cancer stem cell by induction of ros and regulation of stat3 signal |
| topic | cancer stem cells (CSCs) phenylacetaldehyde (PAA) breast cancer Stat3 ROS |
| url | https://www.mdpi.com/2076-3921/9/11/1119 |
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