Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls
Sequential reactions of aminoalkynes represent a powerful tool to easily assembly biologically important polyfunctionalized nitrogen heterocyclic scaffolds. Metal catalysis often plays a key role in terms of selectivity, efficiency, atom economy, and green chemistry of these sequential approaches. T...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/12/4725 |
| _version_ | 1827736243202424832 |
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| author | Antonio Arcadi Valerio Morlacci Laura Palombi |
| author_facet | Antonio Arcadi Valerio Morlacci Laura Palombi |
| author_sort | Antonio Arcadi |
| collection | DOAJ |
| description | Sequential reactions of aminoalkynes represent a powerful tool to easily assembly biologically important polyfunctionalized nitrogen heterocyclic scaffolds. Metal catalysis often plays a key role in terms of selectivity, efficiency, atom economy, and green chemistry of these sequential approaches. This review examines the existing literature on the applications of reactions of aminoalkynes with carbonyls, which are emerging for their synthetic potential. Aspects concerning the features of the starting reagents, the catalytic systems, alternative reaction conditions, pathways and possible intermediates are provided. |
| first_indexed | 2024-03-11T02:06:01Z |
| format | Article |
| id | doaj.art-1d6beefc90274a4b8b85cc049f3a76b7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T02:06:01Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1d6beefc90274a4b8b85cc049f3a76b72023-11-18T11:49:30ZengMDPI AGMolecules1420-30492023-06-012812472510.3390/molecules28124725Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with CarbonylsAntonio Arcadi0Valerio Morlacci1Laura Palombi2Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell’Aquila, Via Vetoio, 67100 Coppito, L’Aquila, ItalyDipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell’Aquila, Via Vetoio, 67100 Coppito, L’Aquila, ItalyDipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell’Aquila, Via Vetoio, 67100 Coppito, L’Aquila, ItalySequential reactions of aminoalkynes represent a powerful tool to easily assembly biologically important polyfunctionalized nitrogen heterocyclic scaffolds. Metal catalysis often plays a key role in terms of selectivity, efficiency, atom economy, and green chemistry of these sequential approaches. This review examines the existing literature on the applications of reactions of aminoalkynes with carbonyls, which are emerging for their synthetic potential. Aspects concerning the features of the starting reagents, the catalytic systems, alternative reaction conditions, pathways and possible intermediates are provided.https://www.mdpi.com/1420-3049/28/12/4725sequential reactionsaminoalkynesheterocyclesmetal catalysis |
| spellingShingle | Antonio Arcadi Valerio Morlacci Laura Palombi Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls Molecules sequential reactions aminoalkynes heterocycles metal catalysis |
| title | Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls |
| title_full | Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls |
| title_fullStr | Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls |
| title_full_unstemmed | Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls |
| title_short | Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls |
| title_sort | synthesis of nitrogen containing heterocyclic scaffolds through sequential reactions of aminoalkynes with carbonyls |
| topic | sequential reactions aminoalkynes heterocycles metal catalysis |
| url | https://www.mdpi.com/1420-3049/28/12/4725 |
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