Reduced genetic influence on childhood obesity in small for gestational age children
<p>Abstract</p> <p>Background</p> <p>Children born small-for-gestational-age (SGA) are at increased risk of developing obesity and metabolic diseases later in life, a risk which is magnified if followed by accelerated postnatal growth. We investigated whether common gen...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2013-01-01
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| Series: | BMC Medical Genetics |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2350/14/10 |
| _version_ | 1818886348927401984 |
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| author | Han Dug Yeo Murphy Rinki Morgan Angharad R Lam Wen Jiun Thompson John M D Wall Clare R Waldie Karen E Mitchell Edwin A Ferguson Lynnette R |
| author_facet | Han Dug Yeo Murphy Rinki Morgan Angharad R Lam Wen Jiun Thompson John M D Wall Clare R Waldie Karen E Mitchell Edwin A Ferguson Lynnette R |
| author_sort | Han Dug Yeo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Children born small-for-gestational-age (SGA) are at increased risk of developing obesity and metabolic diseases later in life, a risk which is magnified if followed by accelerated postnatal growth. We investigated whether common gene variants associated with adult obesity were associated with increased postnatal growth, as measured by BMI z-score, in children born SGA and appropriate for gestational age (AGA) in the Auckland Birthweight Collaborative.</p> <p>Methods</p> <p>A total of 37 candidate SNPs were genotyped on 547 European children (228 SGA and 319 AGA). Repeated measures of BMI (z-score) were used for assessing obesity status, and results were corrected for multiple testing using the false discovery rate.</p> <p>Results</p> <p>SGA children had a lower BMI z-score than non-SGA children at assessment age 3.5, 7 and 11 years. We confirmed 27 variants within 14 obesity risk genes to be individually associated with increasing early childhood BMI, predominantly in those born AGA.</p> <p>Conclusions</p> <p>Genetic risk variants are less important in influencing early childhood BMI in those born SGA than in those born AGA, suggesting that non-genetic or environmental factors may be more important in influencing childhood BMI in those born SGA.</p> |
| first_indexed | 2024-12-19T16:19:55Z |
| format | Article |
| id | doaj.art-1d6cf6230a07424996013348d203e23c |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-19T16:19:55Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-1d6cf6230a07424996013348d203e23c2022-12-21T20:14:31ZengBMCBMC Medical Genetics1471-23502013-01-011411010.1186/1471-2350-14-10Reduced genetic influence on childhood obesity in small for gestational age childrenHan Dug YeoMurphy RinkiMorgan Angharad RLam Wen JiunThompson John M DWall Clare RWaldie Karen EMitchell Edwin AFerguson Lynnette R<p>Abstract</p> <p>Background</p> <p>Children born small-for-gestational-age (SGA) are at increased risk of developing obesity and metabolic diseases later in life, a risk which is magnified if followed by accelerated postnatal growth. We investigated whether common gene variants associated with adult obesity were associated with increased postnatal growth, as measured by BMI z-score, in children born SGA and appropriate for gestational age (AGA) in the Auckland Birthweight Collaborative.</p> <p>Methods</p> <p>A total of 37 candidate SNPs were genotyped on 547 European children (228 SGA and 319 AGA). Repeated measures of BMI (z-score) were used for assessing obesity status, and results were corrected for multiple testing using the false discovery rate.</p> <p>Results</p> <p>SGA children had a lower BMI z-score than non-SGA children at assessment age 3.5, 7 and 11 years. We confirmed 27 variants within 14 obesity risk genes to be individually associated with increasing early childhood BMI, predominantly in those born AGA.</p> <p>Conclusions</p> <p>Genetic risk variants are less important in influencing early childhood BMI in those born SGA than in those born AGA, suggesting that non-genetic or environmental factors may be more important in influencing childhood BMI in those born SGA.</p>http://www.biomedcentral.com/1471-2350/14/10BMIChildhood obesityAGA childrenSGA children |
| spellingShingle | Han Dug Yeo Murphy Rinki Morgan Angharad R Lam Wen Jiun Thompson John M D Wall Clare R Waldie Karen E Mitchell Edwin A Ferguson Lynnette R Reduced genetic influence on childhood obesity in small for gestational age children BMC Medical Genetics BMI Childhood obesity AGA children SGA children |
| title | Reduced genetic influence on childhood obesity in small for gestational age children |
| title_full | Reduced genetic influence on childhood obesity in small for gestational age children |
| title_fullStr | Reduced genetic influence on childhood obesity in small for gestational age children |
| title_full_unstemmed | Reduced genetic influence on childhood obesity in small for gestational age children |
| title_short | Reduced genetic influence on childhood obesity in small for gestational age children |
| title_sort | reduced genetic influence on childhood obesity in small for gestational age children |
| topic | BMI Childhood obesity AGA children SGA children |
| url | http://www.biomedcentral.com/1471-2350/14/10 |
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