Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation
Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural products and their derived biomolecules are potential resources to mine for novel anti-cancer drugs. Chemopreventive effects of safranal, a major bioactive ingredient of the golden spice “saffron”, were ev...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.777500/full |
| _version_ | 1818939615053086720 |
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| author | Youssef Abdalla Ali Abdalla Alaaeldin Ahmed Hamza Amr Amin Amr Amin |
| author_facet | Youssef Abdalla Ali Abdalla Alaaeldin Ahmed Hamza Amr Amin Amr Amin |
| author_sort | Youssef Abdalla |
| collection | DOAJ |
| description | Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural products and their derived biomolecules are potential resources to mine for novel anti-cancer drugs. Chemopreventive effects of safranal, a major bioactive ingredient of the golden spice “saffron”, were evaluated in this study against diethylnitrosamine (DEN)–induced liver cancer in rats. Safranal’s mechanisms of action were also investigated in the human liver cancer line “HepG2”. When administered to DEN-treated rats, safranal significantly inhibited proliferation (Ki-67) and also induced apoptosis (TUNEL and M30 CytoDeath). It also exhibited anti-inflammatory properties where inflammatory markers such as NF-kB, COX2, iNOS, TNF-alpha, and its receptor were significantly inhibited. Safranal’s in vivo effects were further supported in HepG2 cells where apoptosis was induced and inflammation was downregulated. In summary, safranal is reported here as a potent chemopreventive agent against hepatocellular carcinoma that may soon be an important ingredient of a broad-spectrum cancer therapy. |
| first_indexed | 2024-12-20T06:26:33Z |
| format | Article |
| id | doaj.art-1d6d0381c0b5420ebbbecca3bedcc285 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T06:26:33Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-1d6d0381c0b5420ebbbecca3bedcc2852022-12-21T19:50:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-02-011210.3389/fphar.2021.777500777500Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating InflammationYoussef Abdalla0Ali Abdalla1Alaaeldin Ahmed Hamza2Amr Amin3Amr Amin4Department of Kinesiology, Michigan State University, East Lansing, MI, United StatesWeinberg Institute for Cognitive Science, University of Michigan, Ann Arbor, MI, United StatesHormone Evaluation Department, National Organization for Drug Control and Research, Giza, EgyptThe College, The University of Chicago, Chicago, IL, United StatesBiology Department, UAE University, Al Ain, United Arab EmiratesDespite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural products and their derived biomolecules are potential resources to mine for novel anti-cancer drugs. Chemopreventive effects of safranal, a major bioactive ingredient of the golden spice “saffron”, were evaluated in this study against diethylnitrosamine (DEN)–induced liver cancer in rats. Safranal’s mechanisms of action were also investigated in the human liver cancer line “HepG2”. When administered to DEN-treated rats, safranal significantly inhibited proliferation (Ki-67) and also induced apoptosis (TUNEL and M30 CytoDeath). It also exhibited anti-inflammatory properties where inflammatory markers such as NF-kB, COX2, iNOS, TNF-alpha, and its receptor were significantly inhibited. Safranal’s in vivo effects were further supported in HepG2 cells where apoptosis was induced and inflammation was downregulated. In summary, safranal is reported here as a potent chemopreventive agent against hepatocellular carcinoma that may soon be an important ingredient of a broad-spectrum cancer therapy.https://www.frontiersin.org/articles/10.3389/fphar.2021.777500/fullliver cancerpreventionsafranaloxidative stressinflammation |
| spellingShingle | Youssef Abdalla Ali Abdalla Alaaeldin Ahmed Hamza Amr Amin Amr Amin Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation Frontiers in Pharmacology liver cancer prevention safranal oxidative stress inflammation |
| title | Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation |
| title_full | Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation |
| title_fullStr | Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation |
| title_full_unstemmed | Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation |
| title_short | Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation |
| title_sort | safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation |
| topic | liver cancer prevention safranal oxidative stress inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.777500/full |
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