Association Analysis of Free Thyroid Hormones, Subclinical Hypothyroidism, and Thyroid Peroxidase Antibody in the First Trimester with Gestational Diabetes Mellitus
Background: We aimed to investigate the association of free thyroxin (FT4), free triiodothyronine (FT3), subclinical hypothyroidism (SCH), and thyroid peroxidase antibody (TPOab) in the first trimester with gestational diabetes mellitus (GDM). Methods: We recruited 110 pregnant women with GDM and 10...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-09-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009192 |
| _version_ | 1797664521359196160 |
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| author | Yi Zhou Yang Dong |
| author_facet | Yi Zhou Yang Dong |
| author_sort | Yi Zhou |
| collection | DOAJ |
| description | Background: We aimed to investigate the association of free thyroxin (FT4), free triiodothyronine (FT3), subclinical hypothyroidism (SCH), and thyroid peroxidase antibody (TPOab) in the first trimester with gestational diabetes mellitus (GDM). Methods: We recruited 110 pregnant women with GDM and 100 pregnant women without GDM who had normal 75 g oral glucose tolerance test (OGTT) results between June 2019 and June 2021. We collected basic data from all participants and compared serum FT3 and FT4 levels, SCH, and TPOab (+) incidences in the first trimester between the two groups. We used logistic regression to identify factors that influence the development of GDM. Results: Serum FT3 levels were 4.58 ± 0.78 and 4.61 ±1.42 pmol/L in the GDM group and Control group, while FT4 levels were 9.32 ± 2.54 and 10.24 ± 2.77 pmol/L. The incidence of SCH were 25.5% and 14.0%, while TPO (+) were 20.0% and 10.0%. The GDM group’s FT4 levels were significantly lower than the control group’s, whereas the GDM group’s age, incidence of SCH, and TPOab (+) were significantly higher (p < 0.05). Logistic regression analysis demonstrated that age, SCH and TPO (+) were risk factors for GDM (p < 0.05), the regression equation: logit p = –3.484 + 0.105 (age) + 1.128 (SCH) + 1.294 (TPOab (+)). Conclusions: Our findings suggest that monitoring the changes in FT4 levels, SCH, and TPOab (+) incidence in the first trimester may be useful in predicting the occurrence and development of GDM. |
| first_indexed | 2024-03-11T19:30:28Z |
| format | Article |
| id | doaj.art-1d6d441bd8c7400c97f9b3347e789cce |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-11T19:30:28Z |
| publishDate | 2023-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-1d6d441bd8c7400c97f9b3347e789cce2023-10-06T13:17:09ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-09-0150919210.31083/j.ceog5009192S0390-6663(23)02132-2Association Analysis of Free Thyroid Hormones, Subclinical Hypothyroidism, and Thyroid Peroxidase Antibody in the First Trimester with Gestational Diabetes MellitusYi Zhou0Yang Dong1Department of Obstetrics, Jinhua People's Hospital, 321000 Jinhua, Zhejiang, ChinaDepartment of Obstetrics, Jinhua People's Hospital, 321000 Jinhua, Zhejiang, ChinaBackground: We aimed to investigate the association of free thyroxin (FT4), free triiodothyronine (FT3), subclinical hypothyroidism (SCH), and thyroid peroxidase antibody (TPOab) in the first trimester with gestational diabetes mellitus (GDM). Methods: We recruited 110 pregnant women with GDM and 100 pregnant women without GDM who had normal 75 g oral glucose tolerance test (OGTT) results between June 2019 and June 2021. We collected basic data from all participants and compared serum FT3 and FT4 levels, SCH, and TPOab (+) incidences in the first trimester between the two groups. We used logistic regression to identify factors that influence the development of GDM. Results: Serum FT3 levels were 4.58 ± 0.78 and 4.61 ±1.42 pmol/L in the GDM group and Control group, while FT4 levels were 9.32 ± 2.54 and 10.24 ± 2.77 pmol/L. The incidence of SCH were 25.5% and 14.0%, while TPO (+) were 20.0% and 10.0%. The GDM group’s FT4 levels were significantly lower than the control group’s, whereas the GDM group’s age, incidence of SCH, and TPOab (+) were significantly higher (p < 0.05). Logistic regression analysis demonstrated that age, SCH and TPO (+) were risk factors for GDM (p < 0.05), the regression equation: logit p = –3.484 + 0.105 (age) + 1.128 (SCH) + 1.294 (TPOab (+)). Conclusions: Our findings suggest that monitoring the changes in FT4 levels, SCH, and TPOab (+) incidence in the first trimester may be useful in predicting the occurrence and development of GDM.https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009192gestational diabetes mellitusfree hormonessubclinical hypothyroidismthyroid peroxidase antibody |
| spellingShingle | Yi Zhou Yang Dong Association Analysis of Free Thyroid Hormones, Subclinical Hypothyroidism, and Thyroid Peroxidase Antibody in the First Trimester with Gestational Diabetes Mellitus Clinical and Experimental Obstetrics & Gynecology gestational diabetes mellitus free hormones subclinical hypothyroidism thyroid peroxidase antibody |
| title | Association Analysis of Free Thyroid Hormones, Subclinical Hypothyroidism, and Thyroid Peroxidase Antibody in the First Trimester with Gestational Diabetes Mellitus |
| title_full | Association Analysis of Free Thyroid Hormones, Subclinical Hypothyroidism, and Thyroid Peroxidase Antibody in the First Trimester with Gestational Diabetes Mellitus |
| title_fullStr | Association Analysis of Free Thyroid Hormones, Subclinical Hypothyroidism, and Thyroid Peroxidase Antibody in the First Trimester with Gestational Diabetes Mellitus |
| title_full_unstemmed | Association Analysis of Free Thyroid Hormones, Subclinical Hypothyroidism, and Thyroid Peroxidase Antibody in the First Trimester with Gestational Diabetes Mellitus |
| title_short | Association Analysis of Free Thyroid Hormones, Subclinical Hypothyroidism, and Thyroid Peroxidase Antibody in the First Trimester with Gestational Diabetes Mellitus |
| title_sort | association analysis of free thyroid hormones subclinical hypothyroidism and thyroid peroxidase antibody in the first trimester with gestational diabetes mellitus |
| topic | gestational diabetes mellitus free hormones subclinical hypothyroidism thyroid peroxidase antibody |
| url | https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009192 |
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